细胞焦亡在耳鼻咽喉科疾病中的研究进展
Research progress on pyroptosis in otorhinolaryngology diseases
张静祎 1董湘依 2牟亚魁 3宋西成3
作者信息
- 1. 青岛大学附属烟台毓璜顶医院 耳鼻咽喉头颈外科,山东 烟台 264000;山东省文登整骨医院 耳鼻咽喉科,山东 威海 264400
- 2. 烟台市牟平区中医医院 耳鼻喉科,山东 烟台 264100
- 3. 青岛大学附属烟台毓璜顶医院 耳鼻咽喉头颈外科,山东 烟台 264000
- 折叠
摘要
细胞焦亡作为程序性细胞死亡方式中的一种,其过程离不开caspase家族和gasdermin家族,同时伴随着炎性反应的发生,其主要过程是caspase家族被激活后作用于gasdermin家族N端结构,通过易位插入细胞膜表面、寡聚等方式使得细胞膜裂孔形成后体积逐渐膨胀,最终细胞膜破裂,细胞里面的物质从细胞内释放出来,诱发机体产生强烈的炎症性反应.近几年,细胞焦亡为耳鼻咽喉科研究的热点方向之一.本文主要综述细胞焦亡的发现历程、分子机制及其在慢性鼻窦炎、变应性鼻炎、鼻咽癌、听力损失、头颈部肿瘤等耳鼻咽喉科常见疾病中的研究进展.
Abstract
As one of the programmed cell death modes,the process of cell pyroptosis cannot be separated from caspase family and gasdermin family,and accompanied by the occurrence of inflammatory response,the main process is that the caspase family is acti-vated,and then acts on the N-terminal structure of gasdermin family,which causes the cell membrane to be ruptured through trans-location insertion on the surface of the cell membrane,oligomerisation,etc.The cell membrane is then activated by the caspase fam-ily,and the caspases are activated.The cell membrane is then activated by the caspase family and the caspases are activated.After the formation of lacunae,the volume gradually expands and eventually the cell membrane ruptures and the substances inside the cell are released from the cell,triggering a strong inflammatory response in the organism.In recent years,cell death has become one of the hot spots in ENT research.In this article,we review the discovery process,molecular mechanism of cellular pyroptosis and its research progress in common otolaryngological diseases such as chronic sinusitis,allergic rhinitis,nasopharyngeal carcinoma,hear-ing loss,head and neck tumours,and so on.
关键词
细胞焦亡/炎症小体/慢性鼻窦炎/变应性鼻炎/鼻咽癌/听力损失/头颈部肿瘤Key words
Pyroptosis/Inflammatory bodies/Chronic sinusitis/Allergic rhinitis/Nasopharyngeal carcinoma/Hearing loss/Head and neck tumor引用本文复制引用
基金项目
山东省重点研发计划竞争性科技创新平台项目(2022CXPT023)
出版年
2024
NETL
NSTL
万方数据