睑板腺功能障碍实验模型及应用现状
Current status of experimental models and applications of meibomian gland dysfunction
毕赵静 1李元彬2
作者信息
- 1. 潍坊医学院 临床医学院,山东 潍坊 261053;青岛大学附属烟台毓璜顶医院 眼科,山东 烟台 264000
- 2. 青岛大学附属烟台毓璜顶医院 眼科,山东 烟台 264000
- 折叠
摘要
睑板腺功能障碍(meibomian gland dysfunction,MGD)是临床常见的眼表疾病,严重影响患者的日常生活质量.目前MGD发病机制与治疗手段的相关研究已逐渐成为干眼的研究热点,为此建立一个稳定有效的实验模型对于MGD的深入探索是必要的前提.MGD实验模型目前主要分为在体模型和离体模型两大类:在体模型主要通过药物诱导、手术诱导、基因敲除以及转基因方式建模;离体模型是指在体外模拟睑板腺的病理生理.本文就目前报道的多种MGD实验模型及对其应用评价进行简要综述.
Abstract
Meibomian gland dysfunction(MGD)is a common ocular surface disease in clinics that seriously affects the quality of patients'daily life.To date,related research on the pathogenesis and treatment of MGD has gradually become a research hotspot in dry eye.Therefore,the establishment of a stable and effective experimental model is a prerequisite for further exploration of MGD.The experimental models of MGD are divided into two categories:in vivo and in vitro models.The in vivo model is modeled mainly by drug induction,surgical induction,gene knockout,and transgenic methods.The in vitro model is used to simulate the pathophys-iology of meibomian glands in vitro.This paper briefly reviews several MGD experimental models reported so far and their evalua-tion.
关键词
睑板腺功能障碍/干眼/睑板腺上皮细胞/睑板腺外植体/动物模型Key words
Meibomian gland dysfunction/Dry eye/iHMGEC/Meibomian gland explant/Animal models引用本文复制引用
出版年
2024
NETL
NSTL
万方数据