mTOR通路在耳蜗中的研究进展
Research progress on mTOR signaling pathway in cochlea
李钰 1刘皓 1王敏 1付小龙 1李文1
作者信息
- 1. 山东第一医科大学医学科技创新中心,山东济南 250117
- 折叠
摘要
耳聋一直是临床上的治疗难题,随着社会老龄化不断加重,耳聋患者的数量逐年递增,耳聋严重影响患者的生活质量并加重了社会负担.找到关键的干预靶点,对于耳聋的预防和治疗意义重大.mTOR位于细胞生长、代谢、增殖和存活等过程的中心位置.近来,mTOR通路在耳蜗中的作用受到了广泛关注.最新的研究表明,mTOR通路在内耳毛细胞和螺旋神经元的增殖分化、功能维持、衰老及存活中均发挥着重要作用,而内耳毛细胞和螺旋神经元是听觉形成中的关键环节,因此,mTOR信号有希望成为耳聋新的治疗靶点.论文对mTOR通路在耳蜗中的研究现状进行梳理,总结mTOR通路在耳蜗中的调控机制,并探讨该领域未来仍需解决的问题及可能的研究方向.
Abstract
Deafness,a growing clinical challenge exacerbated by societal aging,increasingly affects patients'quality of life and adds to the social burden.Identifying effective intervention targets is crucial for the prevention and treatment of deafness.mTOR(target protein of rapamycin)is central to the processes of cell growth,metabolism,proliferation,and survival.Recent studies suggest that the mTOR pathway is essential for the proliferation,differentiation,maintenance,aging,and survival of cochlear inner ear hair cells and spiral neurons,which are essential for hearing.This paper reviews current research on the mTOR pathway in the cochlea,sum-marizes its regulatory mechanisms,and discusses unresolved issues and potential future research directions,highlighting the promise of mTOR as a novel therapeutic target for deafness.
关键词
mTOR/耳聋/毛细胞/细胞死亡Key words
mTOR/Deafness/Hair cell/Cell death引用本文复制引用
出版年
2024
NETL
NSTL
万方数据