Copper is one of the essential elements required by the human body,being widely involved in various activities.Copper homeostasis is strictly regulated in prolcaryotic and eukaryotic cells to ensure sufficient copper availability for protein biosynthesis and the inhibition of oxidative stress and resulting toxicity.Copper is a limiting factor in the development and progression of cancer,including growth,angiogenesis and metastasis;Therefore,regulating tumor occurrence and development by varying the copper con-tent in the human body has become a popular research topic in tumor treatment.The method adopted for this can be divided into those that increase the copper concentration in tumor cells by administering copper compounds or copper ionophores and those that reduce the copper concentration to physiological levele using copper complexing agents,thereby achieving antitumor therapy.In this paper,the current status and progress of copper complexes in tumor therapy are briefly reviewed,including the known mechanism of action and molecular targets,Furthermore,the related clinical trials are discussed,and the prospects for copper complexes in this field are outlined.
Copper complexAntineoplastonCopper deathCopper ion carrier
NETL
NSTL
万方数据
