M受体信号通路在近视发生发展中作用的研究进展
Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia
张金木 1郭滨 2蒋文君 3刘冬梅4
作者信息
- 1. 山东中医药大学眼科与视光医学院,山东济南 250355
- 2. 山东中医药大学眼科与视光医学院,山东济南 250355;山东中医药大学博士后流动站,山东济南 250355
- 3. 山东省眼病防治研究院实验中心/山东省中西医结合眼病防治重点实验室,山东济南 250002
- 4. 山东中医药大学附属眼科医院白内障科,山东济南 250002
- 折叠
摘要
M受体参与调节众多眼组织生理活动.研究表明,M受体可通过调节睫状肌收缩、调控视网膜和脉络膜中近视相关神经递质(如多巴胺)和生长因子(如转化生长因子β2)的表达来影响巩膜成纤维细胞增殖和基质金属蛋白酶2水平,进而影响巩膜重塑和眼轴增长,最终影响近视的发生发展.近年来,大量动物实验及临床研究均证实M受体拮抗剂可有效延缓近视进展.论文就不同眼组织(睫状肌、视网膜、脉络膜和巩膜)中M受体信号通路在近视发生发展中的作用进行简要综述,以期为近视相关机制研究及临床治疗提供思路.
Abstract
M receptors participate in regulating numerous physiological activities in eye tissues.Studies have shown that M receptors can regulate ciliary muscle contraction,regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factor β2)in the retina and choroid,and affect scleral fibroblast proliferation and matrix metal-loproteinase-2 expression,which in turn affects scleral remodeling and axial growth,ultimately affecting the occurrence and develop-ment of myopia.In recent years,a large number of animal experiments and clinical studies have confirmed that M receptor antago-nists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle,retina,choroid,and sclera),to provide ideas for the studing of myopia-related mechanisms and clinical treatment.
关键词
近视/M受体/睫状肌/视网膜/脉络膜/巩膜Key words
Myopia/M receptor/Ciliary muscle/Retina/Choroid/Sclera引用本文复制引用
基金项目
国家重点研发计划(2021YFC2702103)
山东省自然科学基金面上项目(ZR2020MH393)
山东省博士后创新项目(202101012)
出版年
2024
NETL
NSTL
万方数据