M receptors participate in regulating numerous physiological activities in eye tissues.Studies have shown that M receptors can regulate ciliary muscle contraction,regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factor β2)in the retina and choroid,and affect scleral fibroblast proliferation and matrix metal-loproteinase-2 expression,which in turn affects scleral remodeling and axial growth,ultimately affecting the occurrence and develop-ment of myopia.In recent years,a large number of animal experiments and clinical studies have confirmed that M receptor antago-nists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle,retina,choroid,and sclera),to provide ideas for the studing of myopia-related mechanisms and clinical treatment.
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