抗HIV-1基因治疗新进展
Recent progress in the gene therapies against HIV-1
田雅茹 1焦艳梅 1张彤 1吴昊1
作者信息
- 1. 首都医科大学附属北京佑安医院感染中心,北京,100069
- 折叠
摘要
虽然高效抗反转录病毒治疗(highly active anti-retroviral therapy,HAART)取得了显著的成果,但是抗人类免疫缺陷病毒(human immunodeficiency virus,HIV)药物治疗仍有其局限性(如引起毒素蓄积和病毒突变).基因治疗在理论上具有较好的抗HIV能力,可以通过持续干扰病毒复制,提供了阻止HIV进行性感染的希望.本篇综述主要探讨当前多种基因治疗策略及其最新进展.
Abstract
Highly active antiretroviral therapy (HAART) has achieved significant success, but anti-HIV drug treatment still has its limitation, such as causing drug toxicity and viral-escape mutants. Gene therapy has better ability of anti-HIV in theory. It offers the promise of preventing progressive HIV infection by sustained interference with viral replication. Gene-targeting strategies are being developed with RNA-based agents, such as ribozyme, antisense, RNA aptamers and small interfering RNA, and protein-based agents, such as the mutant HIV Rev protein M10, fusion inhibitors and zinc-finger nucleases. This review mainly discusses the various gene therapy strategies and recent progress. Many of these strategies are being tested in ongoing and planned clinical trials.
关键词
获得性免疫缺陷综合征/人类免疫缺陷病毒1型/基因疗法/慢病毒载体Key words
acquired immune deficiency syndrome ( AIDS)/human immunodeficiency vims type 1 ( HIV-1)/gene therapy/lentivector引用本文复制引用
基金项目
"十二五"国家科技支撑计划重大项目(2012ZX10001-006)
北京市艾滋病研究重点实验室(BZ0089)
出版年
2014
NETL
NSTL
维普
万方数据