Recent progress in the gene therapies against HIV-1
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NETL
NSTL
维普
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虽然高效抗反转录病毒治疗(highly active anti-retroviral therapy,HAART)取得了显著的成果,但是抗人类免疫缺陷病毒(human immunodeficiency virus,HIV)药物治疗仍有其局限性(如引起毒素蓄积和病毒突变).基因治疗在理论上具有较好的抗HIV能力,可以通过持续干扰病毒复制,提供了阻止HIV进行性感染的希望.本篇综述主要探讨当前多种基因治疗策略及其最新进展.
Highly active antiretroviral therapy (HAART) has achieved significant success, but anti-HIV drug treatment still has its limitation, such as causing drug toxicity and viral-escape mutants. Gene therapy has better ability of anti-HIV in theory. It offers the promise of preventing progressive HIV infection by sustained interference with viral replication. Gene-targeting strategies are being developed with RNA-based agents, such as ribozyme, antisense, RNA aptamers and small interfering RNA, and protein-based agents, such as the mutant HIV Rev protein M10, fusion inhibitors and zinc-finger nucleases. This review mainly discusses the various gene therapy strategies and recent progress. Many of these strategies are being tested in ongoing and planned clinical trials.
NETL
NSTL
维普
万方数据
