首页|白芍及白芍总苷治疗自身免疫性皮肤病的作用及机制研究进展

白芍及白芍总苷治疗自身免疫性皮肤病的作用及机制研究进展

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药理研究表明白芍具有抗炎、免疫调节、保肝、镇痛等作用,在临床上白芍及白芍总苷常用于治疗自身免疫性疾病.随着白芍及白芍总苷在抗炎和免疫调节中的作用机制逐步被认识,它们在免疫相关性、炎症性皮肤病中的临床应用得到了不断扩展,通过抗炎、免疫调节和抗氧化等机制在增效减毒、降低疾病复发率方面发挥重要作用.本文对白芍及白芍总苷治疗免疫相关性、炎症性皮肤病的作用及机制的研究进展进行综述,为其深入研究提供依据.
Research progress of effects and mechanisms of paeony and total glucosides of paeony in treatment of immune-associated dermatoses
Pharmacological studies have shown that white paeony has anti-inflammatory,immunomodulatory,hepatoprotective,and analgesic effects.In clinical practice,paeony and total glucosides of paeony are often used to treat autoimmune diseases.As the anti-inflammatory,immune-modulating and anti-oxidizing mechanisms of paeony and total glucosides of paeony are gradually understood,their clinical applications in immune-related and inflammatory skin diseases have been continuously expanded.The mechanisms such as anti-oxidation play an important role in enhancing efficacy,attenuating toxicity,and reducing disease recurrence rates.This article reviews the research progresses on the effects and mechanisms of paeony and total glucosides of paeony in the treatment of immune-related and inflammatory skin diseases,to provide a basis for in-depth research.

paeonytotal glucosides of paeonyautoimmune skin diseasemechanism study

杨阳、陈睿轩、闵力、马致洁、梅雪岭

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首都医科大学附属北京友谊医院教育处,北京 100050

山西医科大学药学院,太原 030001

首都医科大学附属北京友谊医院消化内科,北京 100050

首都医科大学附属北京友谊医院药学部,北京 100050

首都医科大学附属北京友谊医院皮肤性病科,北京 100050

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白芍 白芍总苷 自身免疫性皮肤病 机制研究

首都卫生发展科研专项项目

首发 2022-2-20212

2024

首都医科大学学报
首都医科大学

首都医科大学学报

CSTPCD北大核心
影响因子:1.511
ISSN:1006-7795
年,卷(期):2024.45(1)
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