Preliminary study on brain metabolic characteristics of 18F-FDG PET in new daily persistent headache
Objective To preliminarily study the value of fluorine-18 deoxyglucose(18F-FDG)positron emission tomography(PET)imaging in the metabolic characteristics of various brain regions of new daily persistent headache(NDPH)patients.Methods 18F-FDG PET images of patients with NDPH who underwent 18F-FDG PET examination at the Department of Nuclear Medicine,Beijing Tiantan Hospital,Capital Medical University from May 2021 to July 2023 were collected retrospectively.Cortex ID(GE Healthcare)was used to analyze the PET images and to obtain the Z-score distribution of 26 brain regions of the NDPH patient group.The z-score distribution was applied to evaluate the metabolic characteristics of brain regions of NDPH patients.Results NDPH patients showed reduced metabolism in multiple brain regions such as left/right prefrontal medial region(P=0.004、P=0.009),right posterior cingulate(P=0.003),right precuneus(P=0.003),left sensorimotor(P=0.036),right anterior cingulate(P=0.040),left anterior cingulate(P=0.037),left posterior cingulate(P=0.037),right parietal superior(P=0.002),left parietal superior(P=0.019),left prefrontal lateral(P＜0.001),left/right parietal inferior(P＜0.001),left/right temporal mesial(P＜0.001),right temporal lateral(P＜0.001)and pons(P＜0.001).Conclusion 18F-FDG PET can display metabolic characteristics in different brain regions of NDPH patients,which may provide metabolic information for the pathological mechanism of NDPH and its complications.
new daily persistent headachechronic headachepositron emission tomography/computed tomography18F-fluorodeoxyglucose
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