Factors associated with preoperative 99mTc-MIBI SPECT/CT in patients with suspected primary hyperparathyroidism
Objective To explore the influencing factors of preoperative 99mTc-MIBI single-photon emission computed tomography/computed tomography(SPECT/CT)in patients with suspected primary hyperparathyroidism(PHPT).Methods A total of 257 patients with suspected PHPT who underwent preoperative MIBI SPECT/CT from January 2019 to August 2023 were retrospectively reviewed.The laboratory examination,pathological features,and imaging features between the positive and negative MIBI SPECT/CT groups were compared to each other.Multivariate Logistic regression analysis was used to identify the influencing factors of MIBI SPECT/CT results.Results The serum total calcium,parathyroid hormone(PTH),and alkaline phosphatase(ALP)levels were significantly increased in the positive group than the negative group(P＜0.05);The pathological type,maximum diameter,volume,and location of the lesion showed statistically significant differences between the two groups(P＜0.05).Logistic regression analysis showed that preoperative serum PTH levels,pathological type,location,and maximum diameter of lesions were significantly correlated with positive MIBI SPECT/CT(P＜0.05).Conclusion The preoperative MIBI SPECT/CT in patients with suspected PHPT were affected by multiple factors.The preoperative serum PTH level,pathological type,location and the maximum diameter of the lesion were independent factors for MIBI SPECT/CT.
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