The correlation between systolic blood pressure variability and in-hospital mortality in patients with sepsis
Objective To explore the association between systolic blood pressure variability and in-hospital mortality in patients with sepsis.Methods This study was a prospective,multicenter,and cohort study.Data were derived from the China Critical Care Sepsis Trial,which was conducted from January 2013 to August 2014.Patients aged≥18 years with length of stay of intensive care unit(ICU)more than 24 h were included.The patients who were diagnosed as sepsis for more than 48 h and lack of blood pressure for 2 h or longer were excluded.Systolic blood pressure,diastolic blood pressure,fluid intake and output were collected.The systolic blood pressure coefficient of variation(SBPcv)was calculated and divided into four groups(Q1,Q2,Q3,Q4)according to the interquartile of SBPcv.The multivariable Logistic regression was applied to explore the association between systolic blood pressure variability and in-hospital mortality.Results A total of 1 356 patients with sepsis were included,with 929(68.5%)males and 427(31.5%)females,median age 67.0 years(52.0,78.0).Among them,483(35.6%)patients died during hospitalization.After adjusting for potential confounding factors,for every 10%of SBPcv increasing,the risk of in-hospital mortality increased 43%(OR=1.43,95%CI:1.11-1.98).Compared with Q1 group,patients in Q4 group had a 69%increased risk of in-hospital mortality(OR= 1.69,95%CI:1.31-2.25)and a 23%increased risk of 28 d mortality(OR=1.23,95%CI:1.07-1.84).Conclusion Higher systolic blood pressure variability was correlated with higher risks of in-hospital mortality and 28 d mortality.
sepsisblood pressure variabilitysystolic blood pressure coefficient of variationin-hospital mortality
NETL
NSTL
万方数据
维普
