Cumulative exposure of serum uric acid to serum creatinine ratio and the risk of carotid plaque:a prospective cohort study
Objective To explore the association between cumulative exposure indicators of serum uric acid to serum creatinine ratio(SUA/Scr)and incident carotid plaque.Methods This study included 9 228 individuals who met the inclusion and exclusion criteria from the Beijing Health Management Cohort.The cumulative exposure,cumulative exposure burden and high exposure time of SUA/Scr were calculated based on the values of SUA/Scr in three physical examinations in 2010 to 2011(visit 1),2012 to 2013(visit 2),and 2014 to 2015(visit 3).Carotid plaque was diagnosed by carotid ultrasound,and the follow-up was until December 31,2021.Logistic regression model was used to analyze the association between SUA/Scr cumulative exposure indicators and carotid plaque occurrence,and sensitivity analysis was performed by excluding the participants with the usage of antihypertensive drugs,or glucose-lowering drugs,or lipid-lowering drugs.Results The mean age of the study population was(48.89±10.22)years,and 5 846(63.35%)participants were males.The participants were divided into four groups according to the quartiles of SUA/Scr cumulative exposure,namely Q1-Q4 groups.After adjusting for covariates in models,compared with Q1 group,the ORs(95%CIs)of incident carotid plaque in Q2,Q3 and Q4 groups were 1.221(95%CI:1.066-1.400),1.255(95%CI:1.095-1.439)and 1.478(95%CI:1.287-1.697).Cumulative exposure burden greater than 0(OR=1.223,95%CI:1.109-1.349)and high exposure time of 6 years(OR=1.332,95%CI:1.171-1.515)were both associated with increased risk of carotid plaque occurrence.Sensitivity analysis excluded participants with the usage of any antihypertensive drugs,glucose-lowering drugs,or lipid-lowering drugs.The results were similar to those in main analysis.Conclusion Cumulative exposure,cumulative exposure burden and high exposure time of SUA/Scr were associated with increased risk of incident carotid plaque.In the primary prevention of carotid plaque,we should focus not only on SUA/Scr value at a single point time,but also on long-term monitoring of SUA/Scr values.
serum uric acid to serum creatinine ratiocumulative exposurecarotid plaquecohort study
NETL
NSTL
万方数据
维普
