Effects of vitamin D2 on albuminuria in patients with diabetic kidney disease
Objective To explore the effects of vitamin D2 soft capsules and calcitriol soft capsules on albuminuria in type 2 diabetes mellitus(T2DM)patients with diabetic kidney disease(DKD).Methods Totally 95 T2DM patients with DKD and estimated glomerular filtration rate(eGFR)≥60 mL·(min·1.73 m2)-1 who hospitalized in the department of endocrinology of a tertiary hospital in Beijing from October 2020 to March 2022 were analyzed retrospectively.According to the treatment protocols,the patients were divided into control group without vitamin D preparation(CON group,n=33),natural vitamin D group with vitamin D2 soft capsule(NVD group,n=31),and active vitamin D group with calcitriol soft capsule(AVD group,n=31).The clinical data and parameters of vitamin D and DKD,including serum 25-hydroxyvitamin D(25OHD),serum parathyroid hormone(PTH),blood calcium,urine calcium and urinary albumin-to-creatinine ratio(UACR)at baseline and after 12 weeks treatment were collected through the electronic medical records database system.Results In the baseline phase,there were 8 cases(24.24%),9 cases(29.03%),and 7 cases(22.58%)with macroalbuminuria in CON group,NVD group,and AVD group,respectively,with no significant difference(P=0.831).After 12 weeks of treatment,the level of ln(UACR)decreased significantly(both P<0.001),with no significant difference between the two treatment groups(P=0.371).The total effective rates of NVD group and AVD group were 80.65%and 74.19%respectively,which were significantly higher than those of CON group(33.33%)(P<0.001 and P=0.002).There was no significant difference between NVD group and AVD group(P=0.245).There were 1 case of blood calcium increased,1 case of hypercalciuria,1 case of hyperuricemia,1 case of kidney stone,and 1 case of muscle spasm in CON group,1 case of hypercalciuria and 1 case of hyperuricemia in NVD group,1 case of blood calcium increased,1 case of hypercalcaemia,1 case of blood parathyroid hormone decreased,2 cases of hypercalciuria,and 2 cases of hyperuricemia in AVD group.No drug withdrawal occurred in both treatment groups.Conclusion The administration of both Vitamin D2 soft capsule and calcitriol soft capsule can effectively reduce albuminuria levels in T2DM patients with DKD with good renal function and significantly.Natural vitamin D may be safer compared with active vitamin D.
type 2 diabetes mellitusvitamin D2calcitrioldiabetic kidney diseasealbuminuria
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