Diabetic retinopathy(DR)is one of the common microvascular complications of diabetes and it is the main cause of blindness in adults.In recent years,the treatment of DR has been enriched,and the clinical and basic research related to drug therapy has made great progress.This article summarized the current agents used to treat DR,including calcium dobesilate(CAD),pancreatic kininogenase(PK),fenofibrate,anti-vascular endothelial growth factor(anti-VEGF)drugs,glucagon-like peptide-1 receptor agonist(GLP-1RA),sodium-dependent glucose transporter 2 inhibitors(SGLT-2i),finerenone,antioxidants,natural products and melatonin.