首页|基于ALFF/fALFF的肾虚证认知功能下降的神经机制研究

基于ALFF/fALFF的肾虚证认知功能下降的神经机制研究

The study on neural mechanism of cognitive decline in kidney deficiency syndrome based on ALFF/fALFF

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目的 初步探究肾虚证亚健康人群认知功能改变的神经影像学机制.方法 对 35 例肾虚型亚健康受试者和 35 例健康对照进行重复性成套神经心理状态测验(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)及评估,并进行静息态功能磁共振扫描.应用皮质分析方法 计算两组被试脑区的低频震荡振幅(amplitude of low frequency fluctuations,ALFF)值和分数低频振幅(fractional ALFF,fALFF)值,并分析异常功能活动脑区与认知功能及临床症状之间的相关性.结果 与健康受试者相比,肾虚型亚健康受试者的即刻记忆、注意编码及RBANS测验总分显著降低;并发现其左侧初级视觉皮质、左侧背侧枕叶皮质及右侧辅助运动皮质等脑区的 ALFF/fALFF值异常改变.此外,左侧背侧枕叶皮质、右侧额叶眼动区ALFF值,左侧初级视觉皮质fALFF值与肾虚证积分均成正比.右侧额叶眼动区ALFF值,右侧辅助运动皮质fALFF值与测验总分成反比.结论 肾虚型亚健康受试者的记忆与注意功能受损,左侧枕叶和右侧额叶等多个脑区神经活动的改变可能是肾虚证亚健康人群认知功能改变的潜在神经机制.
Objective To explore the neural mechanisms of cognitive decline of sub-health people with kidney deficiency syndrome.Methods A total of 35 sub-health subjects with kidney deficiency syndrome and 35 matched healthy subjects were recruited in this study.They were assessed with Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),clinical assessment and resting-state functional magnetic resonance imaging scan.Based on a cortical surface-based analysis,the values of amplitude of low frequency fluctuations(ALFF)and fractional ALFF(fALFF)was calculated.Furthermore,the relationships between abnormal functional activity in brain areas,cognitive function and clinical symptoms were analyzed.Results Compared with healthy subjects,sub-health subjects with kidney deficiency syndrome showed significantly lower scores of immediate memory index,attention index,and total scale index.The brain regions with abnormal changed ALFF/fALFF values mainly included the left primary visual cortex,the left dorsal occipital cortex,and the right supplementary motor area.Moreover,the ALFF values of the left dorsal occipital and the right frontal eye fields as well the fALFF values of the left primary visual cortex were positively correlated with kidney deficiency scores.The ALFF values of the right frontal eye fields and the fALFF values of the right supplementary motor area were negatively correlated with total scores of RBANS.Conclusion Impaired memory and attentional functions of were observed in sub-health subjects with kidney deficiency syndrome.The changed neural activity in multiple brain regions,including the left occipital lobe and the right frontal lobe,might be the underlying neural mechanism for declined cognitive function.

kidney deficiencysub-healthresting-state functional magnetic resonance imagingamplitude of low frequency fluctuationsfractional amplitude of low frequency fluctuationsRepeatable Battery for the Assessment of Neuropsychological Status

董麟瑞、冯思同、宁艳哲、吴子遥、贾竑晓

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首都医科大学附属北京安定医院 国家精神疾病医学中心 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室 北京 100088

人脑保护高精尖创新中心,首都医科大学,北京 100069

肾虚证 亚健康 静息态功能磁共振成像 低频震荡振幅 分数低频振幅 重复性成套神经心理状态测验

国家自然科学基金北京市医院管理中心临床医学发展专项北京医院管理中心登峰人才项目

81873398ZYLX202129DFL20191901

2024

10.3969/j.issn.1006-7795.2024.03.011

首都医科大学学报
首都医科大学

首都医科大学学报

CSTPCD北大核心
影响因子：1.511
ISSN：1006-7795
年,卷(期)：2024.45(3)
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