亚健康脾气虚证认知功能及社会功能的研究
Study of cognitive function and social function in the subhealthy people with spleen qi deficiency syndrome
吴子遥 1冯思同 1董麟瑞 1郑思思 1宁艳哲 1贾竑晓1
作者信息
- 1. 首都医科大学附属北京安定医院 国家精神疾病医学中心 国家精神心理疾病临床医学研究中心 精神疾病诊断与治疗北京市重点实验室,北京 100088;人脑保护高精尖创新中心,首都医科大学,北京 100069
- 折叠
摘要
目的 初步探究亚健康脾气虚证受试者认知功能和社会功能的改变.方法 纳入 24 例亚健康脾气虚证受试者和 27例年龄、性别、受教育年限组间匹配的健康受试者.对所有受试者进行重复性成套神经心理状态测验、大体功能量表和脾气虚证亚健康中医证候积分表的评估,并进行统计学分析.结果 与健康受试者相比,亚健康脾气虚证受试者的视觉广度分、注意分、延时记忆分、总分和大体功能量表得分明显降低(P<0.05);而即刻记忆分、言语分组间差异无统计学意义(P>0.05).相关性分析结果 显示延时记忆分(r=-0.532,P=0.009)及总分(r=-0.474,P=0.022)与脾气虚证亚健康中医证候积分呈负相关性,延时记忆分(r=0.564,P=0.004)及总分(r=0.785,P<0.001)与大体功能量表得分呈正相关.结论 亚健康脾气虚证受试者的注意力、记忆力和视空间能力和社会功能受损,其中记忆力与脾气虚症状严重程度以及社会功能密切相关.本研究为从脾论治认知功能异常的相关疾病提供了实验依据,进一步丰富中医"脾藏意"理论内涵.
Abstract
Objective To investigate on the change of cognitive function and social function in subhealthy people with spleen qi deficiency syndrome(SQDS).Methods Totally 24 subhealthy people with SQDS and 27 healthy people matched for age,gender,and education time were evaluated with Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Global Assessment of Functioning Scale(GAF)and Symptom of SQDS Scale.Results Compared with healthy controls,subhealthy people with SQDS showed significantly decreased scores in visuospatial index,attention index,delayed memory index,total scale and GAF(P<0.05),while scores differences in immediate memory index and language index were not statistically significant(P>0.05).Moreover,delayed memory index score(r=-0.532,P=0.009)and total scale score(r=-0.474,P=0.022)were negatively correlated with syndrome of SQDS scale score,but delayed memory index score(r=0.564,P=0.004)and total scale score(r=0.785,P<0.001)were positively correlated with GAF score.Conclusions The impairment of visuospatial ability,attention,memory and social function was observed in subhealthy people with SQDS,and poor memory was significantly associated with symptom of SQDS and social function.It provided experimental evidence for the treatment of dysfunctional cognition diseases from the viewpoint of traditional Chinese medicine theory of spleen and enriched the connotation of spleen stores yi.
关键词
脾气虚证/亚健康/认知功能/社会功能/脾藏意Key words
spleen qi deficiency syndrome/subhealth/cognition function/social function/spleen stores yi引用本文复制引用
基金项目
国家自然科学基金(82174311)
北京市中医药薪火传承"新3+3"工程示范案例项目(2023-ZYSF-19)
出版年
2024
NETL
NSTL
万方数据