Adenosine plays a biological role of signal transduction inside and outside cells by activating different types of adenosine receptors.Adenosine type 1 receptor,as high affinity receptor,is widely expressed in renal tissues,involved in inflammation,immunity,and hemodynamic regulation.At present,the pathogenesis of common kidney disease such as diabetic nephropathy,hypertensive nephropathy and acute kidney injury have not been fully defined.It has been confirmed that adenosine type 1 receptor is involved in the pathological process of various renal diseases such as diabetic nephropathy,renal ischemia-reperfusion injury and contrast nephropathy.We reviewed the advance in researches of adenosine type 1 receptor in renal disease.
adenosine type 1 receptorrenal diseasespathogenesis
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