The impact of body composition on liver and kidney function and blood lipids in patients with polycystic ovary syndrome
Objective To analyze the impact of body composition on liver and kidney function and blood lipids in women with polycystic ovary syndrome(PCOS).Methods This cross-sectional case-control study recruited 678 women aged 20-40 years from the Department of Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,between October 2020 and December 2023.According to the 2004 international Rotterdam criteria,participants were divided into a PCOS group(n=578)and a control group(n=100).Height,weight,waist circumference,and hip circumference were measured,and body mass index(BMI)was calculated.Body fat percentage(BFP)was measured.Alanine transaminase(ALT),aspartate aminotransferase(AST),creatinine(Cre),uric acid(UA),blood urea nitrogen(BUN),total cholesterol(TC),triglycerides(TG),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),and lipoprotein(a)[LP(a)]levels were detected.The impact of body composition on liver function in PCOS was analyzed.Results PCOS group had significantly higher body weight,waist circumference,and BMI than the control group(all P<0.05).ALT,AST,and UA levels in the PCOS group were significantly higher than those in the control group(all P<0.05).There were no statistically significant differences in BUN,Cre,and HDL-C between the PCOS and control groups.The body fat percentage in the PCOS group was significantly higher than that in the control group(P<0.05),with 64.07%of PCOS patients being overweight or obese.The abnormal transaminase rate in the PCOS group was 12.8%,while that in overweight and obese PCOS patients was 17.86%.The abnormal transaminase rate in overweight and obese PCOS patients was significantly higher than that in lean PCOS patients and the control group(both P<0.05).Regarding blood lipids,PCOS patients had significantly higher TC,TG,LDL-C,and LP(a)levels than the control group.Conclusions Patients with PCOS,especially those who are overweight or obese,face higher risk of liver dysfunction and dyslipidemia.Therefore,the management of PCOS patients should pay special attention to the impact of body composition on liver and kidney function as well as lipid levels.The overall health and long-term quality of life of PCOS patients can be improved,through controlling weight,improving insulin resistance,regulating diet,and increasing physical activity.
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