Investigating the temporal characteristics of motor learning deficits in Thy 1-SNCA early Parkinson's disease model mice
Objective In this experiment,a mouse model of early Parkinson's(PD)disease was established to explore the temporal characteristics of PD motor learning deficits.Methods Six-month-old Thy 1-SNCA transgenic mice were selected as an early PD model and compared with wild type(WT)mice for analysis.The mice's motor function and spatial working memory ability were assessed by experiments such as open field test,pole test,and Y-maze test,and the typical accelerating rotarod test was used as a behavioral paradigm for motor learning.Results The six-month-old Thy 1-SNCA transgenic mice did not show abnormalities in motor function and spatial working memory ability,but presented obvious characteristics of motor learning deficits.Conclusions Specific motor learning deficits exist on early PD model mice,which can be used as a detection indicator of early PD.And the typical accelerating rotarod test can be used as a key behavioral method for detecting motor learning deficits in PD.
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