Slit guidance ligand(Slit)is a family of highly conserved secreted glycoproteins that interact with their roundabout guidance receptor(Robo).At present,three Slit genes(Slit 1-3)and four Robo genes(Robo 1-4)have been identified in mammals.Studies have shown that Slit3 has a wide range of biological functions,such as cell migration,bone formation,angiogenesis,and tumorigenesis.At the same time,the mechanisms of Slit3-involved diseases have been investigated,though the pathogenesis of Slit3 is not fully understood.Through studying the pathogenesis of Slit3,we could better explore the pathogenic targets for disease progression and specific treatment.This review summarized the research progress of Slit3 in various diseases,and expounded its role and possible mechanism in related diseases.
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