Diabetic microangiopathy is the most important chronic complication of diabetes mellitus(DM).Studies have shown that nuclear factor-erythroid 2-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling pathway is an important target for the treatment of diabetic microangiopathy.Flavonoids,flavonols,dihydro-flavonoids,isoflavones,dihydroisoflavones,chalcones,flavanols,anthocyanins and other flavonoid monomers of Chinese materia medica can alleviate oxidative stress,reduce inflammatory response,inhibit apoptosis,alleviate fibrosis and improve hemodynamics,etc.by regulating Nrf2/HO-l signaling pathway,so as to achieve the purpose of treating diabetic retinopathy,diabetic cardiomyopathy,diabetic nephropathy,diabetic peri-pheral neuropathy and other diabetic microvascular complications.There are 66 references in total.
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