Overview of Relationship Between OPG/RANKL/RANK Signaling Pathway and Pan Marrow Theory
"Pan Marrow"was a generalization of the rich denotation of the concept of"marrow"in traditional Chinese medicine,including brain,spinal cord,bone marrow and essence.In the relationship of"pan marrow",the brain was the main body,and the essence was an important part of it.The lesions of the brain might affect the essence,and vise versa.Osteoprotegerin signaling pathway could be expressed in multiple systems and organs of the body.It was an important signaling pathway for regulating bone metabolism,and played an irreplaceable role in regulating bone resorption to maintain bone mass.The signaling pathway was most closely related to the brain and essence in the"pan marrow"system,and played a certain regulatory role in the progression of various"marrow"diseases such as cerebrovascular disease,osteoporosis and periodontitis,etc.A variety of cytokines could partici-pate in the inflammatory response related to brain and essence lesions by regulating the expression of osteoprotegerin signaling system.The regulation of calcium metabolism by osteoprotegerin signaling system might be one of the pathways of the metabo-lism of the body's essence.There are 48 references in total.
万方数据
维普
