不同基原、炮制品及混伪品没药饮片的DSC图谱鉴别研究
DSC Thermogram Identification of Decoction Pieces of Moyao(Myrrha)of Different Medicinal Origins,Processed Products and Counterfeit Species
苏玉纯 1沈紧治 1谢素治 2田婧3
作者信息
- 1. 厦门大学附属中山医院药学部,福建厦门 361004
- 2. 厦门市海沧医院药学部,福建厦门 361026
- 3. 北京同仁堂科技发展股份有限公司制药厂,北京 100075
- 折叠
摘要
目的:建立差示扫描量热法(DSC)鉴别区分天然没药、胶质没药、没药炮制品、没药混伪品.方法:收集不同基原、炮制品、混伪品的没药样品,通过考察升温范围、升温速率、粒度大小等因素对没药DSC试验条件的影响,在优化条件下应用差示扫描量热仪对没药各样品进行差热图谱扫描、对比分析.结果:DSC试验优化条件为升温范围-25～550 ℃、粒度大小100目、升温速率50 ℃/min;130 ℃附近的吸热峰与330 ℃附近的放热峰为没药的特征峰.天然没药、胶质没药在130 ℃和330 ℃位置特征峰的平均温度、热焓值均有明显差异,天然没药在两位置的热焓值均明显低于胶质没药.通过比对特征峰可以清晰地鉴别出伪品(松脂、枫香脂)在130 ℃和330 ℃附近位置均无该特征峰,混伪品枫香脂在10 ℃有吸热特征峰,混伪品松脂在150 ℃附近有明显的放热峰;醋制天然没药在180 ℃与240 ℃附近特征峰的热焓值均比天然没药低.结论:DSC试验可快速准确鉴别天然没药、胶质没药、伪品枫香脂及松脂;DSC可快速区分醋制没药与没药;130 ℃吸热峰、330 ℃放热峰为没药特征峰.
Abstract
Objective:To establish the differential scanning calorimetry(DSC)for distinguishing natural Moyao(Myrrha),colloidal Moyao,processed Moyao and its counterfeit species.Methods:The samples of Moyao from different medicinal sources,processed products and counterfeit species were collected.By investigating the effect of heating range,heating rate,particle size and other factors on the DSC test con-ditions of Moyao,the differential thermal map of each sample of Moyao was scanned and analyzed by DSC under the optimized conditions.Results:The optimized DSC test conditions were as follows:the heating range of-25 to 550 ℃,the particle size of 100 mesh,and the heating rate of 50 ℃/min.The endothermic peak near 130 ℃ and the exothermic peak near 330 ℃ were the characteristic peaks of Moyao.The average temperature and enthalpy values of characteristic peaks at 130 ℃ and 330 ℃ of natural Moyao and colloid Moyao were significantly different,and the enthalpy values of natural Moyao were significantly lower than those of colloid Moyao.The counterfeit species[turpentine,Fengxiangzhi(Liquidambaris Resina)]could be clearly identified through comparing the characteristic peaks,which had no characteristic peak near 130 ℃ and 330 ℃.There was an endothermic peak at 10 ℃ for the counterfeit Fengxiangzhi,and an obvious exothermic peak near 150 ℃ for the counterfeit turpentine.The enthalpy values of characteristic peaks near 180 ℃ and 240 ℃ of natural Moyao processed with vinegar were lower than those of natural Moyao.Conclusions:DSC test could quickly and accurately distinguish natural Moyao,colloid Moyao,counterfeit Fengxiangzhi and turpentine,and could quickly distinguish Moyao processed with vinegar and Moyao.Endothermic peak at 130 ℃ and exothermic peak at 330 ℃ were the characteristic peaks of Moyao.
关键词
天然没药/胶质没药/混伪品/枫香脂/松脂/差示扫描量热法/鉴别研究Key words
natural Moyao(Myrrha)/colloidal Moyao(Myrrha)/counterfeit species/Fengxiangzhi(Liquidambaris Resina)/turpentine/differential scanning calorimetry/identification study引用本文复制引用
基金项目
福建省自然科学基金项目(2021J05276)
厦门市医疗卫生指导性项目(3502Z20199027)
出版年
2024
国家科技期刊平台
NSTL
万方数据