Research Progress on Antiviral and Anti-inflammatory Effects of Tetrandrine
This paper reviewed the domestic and foreign research literature on the anti-viral effects of tetrandrine on coronavirus type Ⅱ of severe acute respiratory syndrome,porcine epidemic diarrhea virus and dengue virus,as well as its anti-inflammatory effects on rheumatic immune system,the respiratory system,nervous system,digestive system,and other diseases.It was concluded that tetrandrine can act as a two-pore channel antagonist to inhibit the entry and replication of the virus to play an antiviral role.It can also regulate the production of inflammatory factors by regulating nuclear transcription factor-κB(NF-κB),Janus kinase signal transduction and activator of transcription(JAK-STAT),cyclooxygenase/prosta-glandin E2(COX/PGE2),Nod-like receptor protein 3(NLRP3)and other related signaling pathways,and further regulate the antiviral immunity of the body.Ultimately,it exerts anti-inflammatory and antiviral effects.This paper mainly analyzed the intervention effect and mechanism of tetrandrine on coronavirus,Ebola virus and other viruses,as well as the mechanism involved in its anti-inflammatory effect,aiming to provide reference for further medicinal research and application of tetrandrine in the future.There are 70 references in total.
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