Clinical Study on Wendan Decoction(温胆汤)Combined with Acupuncture in Treatment of Anxiety and Depression After Breast Cancer Surgery
Objective:To observe the clinical efficacy of Wendan Decoction(温胆汤)combined with acupuncture in the treatment of anxiety and depression after breast cancer surgery.Methods:A total of 130 patients with anxiety and depression after breast cancer surgery were randomly divided into a control group(32 cases),an acupuncture group(31 cases),a Wendan Decoction group(35 cases)and a combined group(32 cases)by envelope method.All of the four groups were treated with conventional western medicine,the acupuncture group was treated with acupuncture on this basis,the Wendan Decoction group was treated with Wendan Decoction on this basis,and the combined group was treated with acupuncture and Wendan Decoction on this basis.The curative efficacy was evaluated after 12 weeks of treatment for all groups.Before treatment,after 4 weeks of treatment,and after 12 weeks of treatment,the anxiety and depression levels of the patients in each group were assessed using the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),self-rating anxiety scale(SAS),and self-rating depression scale(SDS).The serum levels of 5-hydroxytryptamine(5-HT),dopamine(DA),brain-derived neurotrophic factor(BDNF),and neuropeptide Y(NPY)were measured before and after treatment.Results:After treatment,the total effective rate of the combined group was higher than that of the control group,the acupuncture group,and the Wendan Decoction group(P＜0.05).The scores of each scale at each time point after treatment were lower than those before treatment in all the four groups(P＜0.05).After 4 weeks and 12 weeks of treatment,the HAMD,HAMA,SAS,and SDS scores of the combined group were lower than those of the other three groups(P＜0.05),and the HAMD,HAMA,SAS,and SDS scores of the acupuncture group and the Wendan Decoction group were lower than those of the control group(P＜0.05).Repeated measurement A NOVA showed that treatment method and treatment time had an interaction effect on HAMD,HAMA,SAS,and SDS scores(P＜0.05),and both were the main effects in the scores(P＜0.05),with actual effect size(η2)ranging from 0.53 to 0.97.After treatment,the levels of BDNF,NPY,DA,and 5-HT in all the four groups were increased compared to those before treatment(P＜0.05).The levels of BDNF,NPY,DA,and 5-HT in the acupuncture group,Wendan Decoction group,and combined group were higher than those in the control group(P＜0.05),and the levels of BDNF,NPY,DA,and 5-HT in the combined group were higher than those in the acupuncture group and the Wendan Decoction group(P＜0.05).Conclusions:Wendan Decoction combined with acupuncture has a definite curative efficacy on anxiety and depression after breast cancer surgery,which can effectively reduce the severity of patients'anxiety and depression,and improve the levels of peripheral blood neurotransmitters.
breast cancerpostoperativeanxietydepressionWendan Decoctionacupunctureneurotransmitters
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