Clinical Study of Electroacupuncture Combined with Repetitive Transcranial Magnetic Stimulation in Treatment of Mild Cognitive Impairment After Ischemic Stroke
Objective:To observe the clinical efficacy of electroacupuncture combined with repetitive transc-ranial magnetic stimulation in the treatment of mild cognitive impairment after ischemic stroke.Methods:A total of 106 patients with mild cognitive impairment after ischemic stroke were divided into a control group and an observation group by the random number table method,with 53 cases in each group.The control group received repetitive transcranial magnetic stimulation treatment on the basis of conventional treatment,while the observation group received electroacupuncture treatment on the basis of the control group.The National Institutes of Health Stroke Scale(NIHSS)scores,Montreal Cognitive Assessment(MoCA)scores,and Stroke-Specific Quality of Life(SS-QOL)scores before and after treatment were compared between the two groups,along with levels of serum indicators related to the disease condition[including soluble vascular endothelial growth factor(VEGF),VEGF receptor 1(sFlt-1),brain-derived nerve growth factor(BDNF),tumor necrosis factor-α(TNF-α),carboxyl terminal hydrolase 1(UCH-L1),neuron specific enolase(NSE),neuronal PAS domain protein 4(NPAS4),malondialdehyde(MDA),superoxide dismutase(SOD)]and brain oxygen metabolism indicators[including arterial-venous oxygen content difference(Ca-vO2),arterial oxygen content(CaO2),and cerebral oxygen uptake rate(CERO2)],to evaluate the clinical efficacy of the two groups.Results:After treatment,the NIHSS scores of both groups were decreased compared to those before treatment(P＜0.05),while the MoCA and SS-QOL scores of both groups were increased compared to those before treatment(P＜0.05).The MoCA and SS-QOL scores of the observation group were higher than those of the control group(P＜0.05),while the NIHSS score of the observation group was lower than that of the control group(P＜0.05).After treatment,the levels of SOD,VEGF,and BDNF in both groups were increased compared to those before treatment(P＜0.05),while the levels of UCH-L1,TNF-α,MDA,sFlt-1,CaO2,Ca-vO2,CERO2,NSE,and NPAS4 in both groups were decreased compared to those before treatment(P＜0.05).The levels of SOD,VEGF,and BDNF in the observation group were higher than those in the control group(P＜0.05),and the levels of UCH-L1,TNF-α,MDA,sFlt-1,CaO2,Ca-vO2,CERO2,NSE,and NPAS4 in the observation group were lower than those in the control group(P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group(P＜0.05).Conclusions:Electroacupuncture combined with repetitive transcranial magnetic stimulation has definite curative efficacy on mild cognitive impairment after ischemic stroke.It can reduce oxidative stress damage and inflammatory responses,promote vascular regeneration,improve cerebral oxygen metabolism,repair neural and cognitive function damage,and enhance life quality and curative efficacy of the patients.
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