首页|从金水相生论治干燥综合征相关性间质性肺疾病

从金水相生论治干燥综合征相关性间质性肺疾病

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干燥综合征(SS)属燥痹范畴,燥易伤肺,故累及肺脏可发为肺痹、肺痿,出现干燥综合征相关性间质性肺疾病(SS-ILD),其病机复杂且较为难治。中医肺肾两脏生理功能失常导致的气运失常、水液代谢失常为SS-ILD发病的重要病因病机。SS-ILD的病机演变为:前期燥邪伤肺,气失宣散;中后期由肺及肾,气血两伤。故提出从金水相生论治SS-ILD,具体应用包括清养肺阴、滋补肾阴以改善糖皮质激素及非甾体类抗炎药的不良反应;行气活血、温阳化饮祛除SS-ILD发病中痰饮、疲血等病理因素;针对SS-ILD中的久病久虚患者,采取肺肾二脏同补,同时面对虚中夹实的患者,补泻并施,以求正气与肺肾二脏之职得复。
Treatment of Interstitial Lung Disease Associated with Sj?gren's Syndrom from Mutual Generation of Metal and Water
Sjögren's syndrome(SS)belongs to the category of dryness arthralgia,dryness is easy to injure the lungs,so it can cause lung arthralgia and lung flaccidity,and leads to Sjögren's syndrome-associated interstitial lung disease(SS-ILD),of which the pathogenesis is complex and it is difficult to treat.The important etiology and pathogenesis of SS-ILD are qi transportation disorder and water metabolism disorder caused by physiological dysfunction of lung and kidney in traditional Chinese medicine.The pathogenesis of SS-ILD evolves as follows:in the early stage,the lung is injured by dryness evil,and qi is dissipated.In the middle and late stage,the lung and kidney,qi and blood are injured.Therefore,it is proposed to treat SS-ILD from the theory of the mutual generation of metal and water,the specific applications include clearing and nourishing lung yin,nourishing kidney yin to improve the adverse reactions of glucocorticoids and non-steroidal anti-inflammatory drugs.Activating qi to promote blood circulation and warming yang and resolving fluid retention to eliminate the pathological factors such as phlegm and blood stasis in SS-ILD.For the chronic disease and deficiency in SS-ILD patients,the lung and kidney are supplemented together.Meanwhile,for the patients with deficiency and mixed with excessiveness,supplementing and purging should be applied in order to recover healthy qi and the functions of the lung and kidney.

Sjögren's syndromeinterstitial lung diseasethe mutual generation of metal and waterlungkidney

王怡然、张伟

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潍坊市中医院,山东潍坊 261000

山东中医药大学附属医院,山东济南 250014

干燥综合征 间质性肺疾病 金水相生

国家自然科学基金面上项目

81874442

2024

山东中医杂志
山东中医药学会 山东中医药大学

山东中医杂志

CSTPCD
影响因子:0.431
ISSN:0257-358X
年,卷(期):2024.43(3)
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