Clinical Study on Wenyang Tongmai Decoction(温阳通脉汤)Combined with Western Medicine in Treating Angina Pectoris of Coronary Heart Disease
Objective:To investigate the clinical effect of Wenyang Tongmai Decoction(温阳通脉汤)combined with isosorbide mononitrate and nicodil on angina pectoris of coronary heart disease.Methods:A total of 160 patients with angina pectoris of coronary heart disease were selected and divided into the control group and the observation group according to random number table method,with 80 cases in each group.The control group was treated with isosorbide mononitrate and nicodil,and the observation group was combined with Wenyang Tongmai Decoction on the basis of the treatment of the control group.After a continuous treatment of 2 months,angina pectoris attack and traditional Chinese medicine(TCM)syndrome score,blood lipids[total cholesterol(TC),triglycerides(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)],inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),soluble intercellular adhesion molecule-1(sICAM-1)]were compared between the two groups.Results:After treatment,the frequency and duration of angina pectoris in both groups were lower than those before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).The score of Seattle Angina Questionnaive(SAQ)in both groups was higher than that before treatment(P＜0.05),and the observation group was higher than the control group(P＜0.05).After treatment,the levels of TC,TG and LDL-C in both groups were lower than those before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).HDL-C in both groups was higher than that before treatment(P＜0.05),and the observation group was higher than the control group(P＜0.05).After treatment,the levels of hs-CRP,IL-6 and sICAM-1 in both groups were lower than those before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).After treatment,the scores of palpitation,chest pain and shortness of breath in both groups were lower than those before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).After treatment,the incidence of adverse reactions was 12.50％in the control group and 3.75％in the observation group,and the incidence of adverse reactions in the observation group was better than that in the control group(P＜0.05).Conclusions:Wenyang Tongmai Decoction combined with isosorbide mononitrate and nicordil is effective in the treatment of angina pectoris of coronary heart disease,which can effectively improve the blood lipid index,reduce the level of inflammation and improve the occurrence of adverse reactions.
万方数据
维普
