Clinical Observation of Yishen Zhuyu Jiedu Therapy in Treatment of Malnutrition-Inflammation-Atherosclerosis(MIA)Syndrome in Maintenance Hemodialysis Patients
Objective:To observe the clinical effect of Yishen Zhuyu Jiedu therapy in the treatment of maintenance hemodialysis(MHD)with malnutrition-inflammation-atherosclerosis(MIA)syndrome and its effect on occurrence of cardiovascular and cerebro-vascular events.Methods:A total of 91 MHD patients with MIA syndrome were selected and divided into the observation group(47 cases)and the control group(44 cases)according to random number table method.The control group was treated with conventional western medicine,and the observation group was treated with Yishen Zhuyu Jiedu Chinese medicine on the basis of the treatment of the control group.The inflammatory indexes[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],nutritional status[serum albumin(ALB),body mass index(BMI),upper arm muscle circumference(AMC)],carotid atherosclerosis indexes[intima-media thickness(IMT),plaque area]and occurrence of cardiovascular and cerebrovascular events and adverse reactions of two groups before and after treatment were compared.Results:After treatment,the levels of IL-6,CRP and TNF-α in both groups were lower than those before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).ALB,BMI and AMC in both groups were higher than those before treatment(P＜0.05),and the observation group was higher than the control group(P＜0.05).Carotid IMT and bilateral carotid plaque area in both groups were lower than those before treatment(P＜0.05),and the obser-vation group was lower than the control group(P＜0.05).The incidence of cardiovascular and cerebrovascular events in the observation group was 22.22％,lower than 43.90％in the control group,and the difference was statistically significant(P＜0.05).No serious adverse reactions occurred in both groups.Conclusions:Yishen Zhuyu Jiedu Chinese medicine preparation can relieve the malnutrition,inflammation,atherosclerosis of MHD with MIA syndrome patients,and reduce the incidence of cardiovascular and cerebrovascular events.
Yishen Zhuyu Jiedu therapymaintenance hemodialysismalnutritioninflammationatherosclerosiscardiovascular and cerebrovascular events
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维普
