基于光学相干断层扫描血管成像术探讨Eye-TEAS防治儿童近视疗效及作用机制

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中文摘要：目的:基于光学相干断层扫描血管成像术(OCTA)探讨眼周经皮穴位电刺激仪(Eye-TEAS)防治儿童近视的疗效和机制。方法:纳入60名近视儿童，记录黄斑中心凹下脉络膜厚度(SFCT)等眼部各参数水平，并对各参数进行相关性分析;采用Eye-TEAS对受试者进行3个月的干预治疗，每天30 min，每周使用不低于5次。检测Eye-TEAS干预前、干预1次后、干预1个月后、干预3个月后受试者等效屈光度(SER)、眼轴长度(AL)、SFCT及黄斑区3mm×3mm面积内的脉络膜中大血管密度(CVD)、脉络膜毛细血管密度(CCVD)的变化情况。结果:58名近视儿童完成了干预及随访，在基线数据观察中，SER与SFCT、CCVD均呈显著正相关(P＜0。01)，AL与SER、SFCT、CVD、CCVD呈显著负相关(P＜0。05或P＜0。01)。相较于干预前，干预第1次后、1个月后、3个月后SER、AL均未发生显著变化(P＞0。05)。干预第1次后SFCT与基线水平比较，差异无统计学意义(P＞0。05)。干预1个月、3个月后SFCT与基线水平比较，差异均有统计学意义(P＜0。05)，其中干预1个月后SER变化和SFCT变化呈显著正相关(P＜0。05)。在干预第1次、干预1个月后CVD较基线水平增加(P＜0。05)，但干预3个月后CVD与基线水平比较，差异无统计学意义(P＞0。05)。相较于基线数据，干预1个月后和干预3个月后CCVD均显著升高(P＜0。01)。结论:近视儿童SFCT、眼底微循环情况与AL、SER具有高度相关性;Eye-TEAS干预后SFCT显著增厚，CVD、CCVD也显著增加，这可能与Eye-TEAS通过影响脉络膜血流的变化减缓近视的进展有关。

外文标题：Exploration on Efficacy and Mechanism of Eye-TEAS in Preventing and Treating Myopia in Children Based on Optical Coherence Tomography Angiography

外文摘要：Objective:To explore the efficacy and mechanism of eye peripheral transcutaneous electrical acupoint stimulation device(Eye-TEAS)in preventing and treating myopia in children based on optical coherence tomography angiography(OCTA).Methods:Total 60 myopic children were included,the level of ocular parameters such as subfoveal choroidal thickness(SFCT)of the macular center pits were recorded and correlation analysis was performed for each parameter.And Eye-TEAS was used to intervene in the subjects for 3 months with 30 min per day,which was no less than 5 times per week.The changes of the subjects'spherical equivalent refraction(SER),axial length(AL),SFCT,and the vessel density of large vessels in the choroid(CVD)and the vessel density of the choroidal capillaries(CCVD)in the area of the macula measuring 3 mm × 3 mm were observed before the Eye-TEAS intervention,after the first intervention,after 1 month,and after 3 months of the intervention.Results:Total 58 myopic children completed the intervention and follow-up.In the baseline data observation,SER was significantly positively correlated with SFCT and CCVD(P＜0.01),while AL was significantly negatively correlated with SER,SFCT,CVD and CCVD(P＜0.05 or P＜0.01).Compared with the pre-intervention period,there were no significant changes in SER and AL after the first intervention,after 1 month,and after 3 months.There was no statistically significant difference between SFCT and baseline level after the first intervention(P＞0.05).There were statistically significant differences between SFCT and baseline level after 1 month and 3 months of intervention(P＜0.05).There was a significant positive correlation between SER changes and SFCT changes after 1 month of intervention(P＜0.05).CVD increased at the first intervention and 1 month after intervention(P＜0.05),but there was no statistically significant difference between CVD and baseline level after 3 months of intervention(P＞0.05).Compared with baseline data,CCVD significantly increased at 1 month and 3 months after intervention(P＜0.01).Conclusions:SFCT and fundus microcirculation in myopic children are highly correlated with AL and SER.After the intervention of Eye-TEAS,SFCT thickens significantly,and CVD and CCVD also increase significantly,which may be related to the fact that Eye-TEAS slows down the progression of myopia by affecting the changes in choroidal blood flow.

外文关键词：

myopia in childrenchoroidoptical coherence tomography angiographyeye peripheral transcutaneous electrical acupoint stimulationspherical equivalent refractionaxial length

作者：

唐国栋、常翠鸣、杨振宁、宋继科、毕宏生

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作者单位：

山东中医药大学附属眼科医院,山东济南 250002

齐鲁理工学院,山东济南 250200

山东中医药大学,山东济南 250355

关键词：

儿童近视脉络膜光学相干断层扫描血管成像眼周经皮穴位电刺激等效屈光度眼轴长度

基金：

山东省自然科学基金项目山东省医药卫生科技发展计划项目山东省重点研发计划(重大科技创新工程)项目济南市科技创新发展计划(临床医学科技创新计划)项目

项目编号：

ZR2021LZY0452021070209112021LCZX09202134044

出版年：

2024

DOI：

10.16295/j.cnki.0257-358x.2024.03.012

山东中医杂志

山东中医药学会山东中医药大学

山东中医杂志

CSTPCD

影响因子：0.431

ISSN：0257-358X

年,卷(期)：2024.43(3)

参考文献量29