Effect and Mechanism of Acupuncture Combined with Xifeng Huatan Tongluo Granule(息风化痰通络颗粒)on Thrombolytic Patients with Acute Cerebral Infarction
Objective:To evaluate the therapeutic effect of acupuncture combined with Xifeng Huatan Tongluo Granule(息风化痰通络颗粒)on thrombolytic patients with acute cerebral infarction(ACI),and to explore the mechanism of action.Methods:After thrombolysis,178 patients with ACI were included and divided into the observation group and the control group according to random number table method,with 89 patients in each group.Finally,164 patients completed the study,with 81 in the observation group and 83 in the control group.The control group received conventional treatment,and the observation group was treated with acupuncture combined with Xifeng Huatan Tongluo Granule on the basis of the treatment of the control group.Both groups were treated for 2 weeks.The clinical efficacy,National Institutes of Health Stroke Scale(NIHSS)score,Activities of Daily Living Scale(ADL)score,serum levels of inflammatory factors,oxidative stress factors and cerebral hemodynamics were evaluated and compared between the two groups.Results:After treatment,the levels of ADL score,interleukin-10(IL-10),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase(CAT)in both groups were higher than those before treatment(P＜0.05).The levels of NIHSS score,interleukin-1β(IL-1β),hypersensitive C-reactive protein(hs-CRP)and malondialdehyde(MDA)were lower than those before treatment(P＜0.05),and the levels of NIHSS score,IL-1 β,IL-10,hs-CRP and MDA in the observation group were lower than those in the control group(P＜0.05).ADL score,SOD,GSH-Px and CAT levels in the observation group were higher than those in the control group(P＜0.05).The indexes of cerebral hemodynamics in both groups were improved compared with those before treatment,and the improvement in the observation group was better than that in the control group(P＜0.05).The total effective rate was 95.06％in the observation group and 84.34％in the control group.The difference of therapeutic effect between the two groups was statistically significant(P＜0.05).Conclusion:Acupuncture combined with Xifeng Huatan Tongluo Granule can promote cerebral hemodynamic recovery and improve the nerve functional disorder caused by ischemia-reperfusion,and its mechanism may be related to reducing inflammation and inhibiting oxidative stress.
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