首页|中西医结合治疗母细胞性浆细胞样树突状细胞肿瘤伴噬血细胞综合征个案报道

中西医结合治疗母细胞性浆细胞样树突状细胞肿瘤伴噬血细胞综合征个案报道

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母细胞性浆细胞样树突状细胞肿瘤(BPDCN)起病急,预后差,目前没有特定的诊疗指南及专家共识。本案在疾病确诊后先行3周期噬血细胞综合征-1994(HLH-1994)方案治疗噬血细胞综合征,达到临床完全缓解后选用CHOP方案化疗治疗BPDCN,治疗过程中药及中医适宜技术如火龙灸等全程参与。中医治疗整体可分3期,初期以益气补虚、清热解毒、凉血散瘀为治疗原则,方选犀角地黄汤加减;中期以益气补血、健脾消食、填精益髓为治疗原则,方选归脾汤加减;后期为巩固治疗时期,以益气化痰健脾、补肾壮骨为主要治疗原则,方选香砂六君汤加减。
A Case Report on Integrated Chinese and Western Medicine Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm with Hemophagocytic Syndrome
Blastic plasmacytoid dendritic cell neoplasm(BPDCN)has an urgent onset and poor prognosis,and there is no specific diagnosis and treatment guideline or expert consensus.In this case,the hemophagocytic syndrome-1994(HLH-1994)regimen was used to treat the hemophagocytic syndrome for 3 courses after the diagnosis of the disease,and chemotherapy with CHOP regimen was used to treat BPDCN after the clinical complete remission was achieved.Chinese medicine and appropriate techniques of traditional Chinese medicine(TCM)such as fire dragon moxibustion were involved in the whole treatment process.The whole TCM treatment can be divided into 3 stages.During the initial stage,the treatment principles were supplement-ing qi and tonifying deficiency,clearing heat and detoxification,cooling blood and dispersing blood stasis,and the prescription was modified Xijiao Dihuang Decoction(犀角地黄汤).In the middle stage,the treatment principles were supplementing qi and blood,invigorating spleen and eliminating food stagnation,and supplementing essence and replenishing marrow,and the prescription was modified Guipi Decoction(归脾汤).The last stage was for consolidation of treatment,the treatment principles were supplementing qi and eliminating phlegm to strengthen spleen,tonifying kidney and strengthening bones,and the prescription was modified Xiangsha Liujun Decoction(香砂六君汤)

blastic plasmacytoid dendritic cell neoplasmhemophagocytic syndromeXijiao Dihuang DecoctionGuipi DecoctionXiangsha Liujun Decoctionfire dragon moxibustion

彭海艳、胡远强、胡海峰、谭志洪、黄文

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三峡大学附属第二人民医院中西医结合肿瘤科,湖北宜昌 443099

母细胞性浆细胞样树突状细胞肿瘤 噬血细胞综合征 犀角地黄汤 归脾汤 香砂六君汤 火龙灸

2024

山东中医杂志
山东中医药学会 山东中医药大学

山东中医杂志

CSTPCD
影响因子:0.431
ISSN:0257-358X
年,卷(期):2024.43(5)
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