Clinical Study on Qinghua Formula(清化方)in Treatment of Non-Alcoholic Fatty Liver Disease with Dampness-Heat Accumulation Syndrome
Objective:To observe the clinical efficacy of Qinghua Formula(清化方)in the treatment of non-alcoholic fatty liver disease(NAFLD).Methods:A total of 66 patients with NAFLD were divided into a control group and an observation group by the random number table method,with 33 cases in each group.Due to dropouts during the study,there were ultimately 30 cases in the control group and 32 cases in the observation group.Both groups received lifestyle interventions,while the observation group also received intervention with Qinghua Formula.In both groups,each course of treatment lasted for 12 weeks,and a total of two courses were administered.Controlled attenuation parameter(CAP),blood lipid metabolism indicators,liver function indicators,blood glucose metabolism indicators,and body mass index(BMI)were observed before intervention,after 12 weeks of intervention,and after 24 weeks of intervention in both groups.The clinical curative efficacy on abdominal B-ultrasound and traditional Chinese medicine(TCM)syndrome after 24 weeks of intervention were evaluated.Results:①Aft er 12 weeks and 24 weeks of intervention,the level of CAP was decreased compared to that before intervention in both groups(P＜0.05).After 24 weeks of intervention,the level of CAP was lower than that after 12 weeks of intervention in both groups(P＜0.05).After 12 weeks and 24 weeks of intervention,the level of CAP in the observation group was lower than that in the control group(P＜0.05).②After 24 weeks of intervention,the level of TG in the observation group was lower than that before intervention and that after 12 weeks of intervention(P＜0.05),and it was also lower than that in the control group at the same time point(P＜0.05).③ After 24 weeks of intervention,the level of fasting insulin(FINS)and the result of homeostasis model assessment of insulin resistance(HOMA-IR)in the observation group were lower than those before intervention,and they were also lower than those in the control group at the same time point(P＜0.05).④After 12 weeks and 24 weeks of intervention,the BMI was lower than that before intervention and that after 12 weeks of intervention in both groups(P＜0.05).After 24 weeks of intervention,the BMI in the observation group was decreased compared to that after 12 weeks of intervention(P＜0.05),and it was also lower than that in the control group at the same time point(P＜0.05).⑤After 24 weeks of intervention,both the clinical curative efficacy of abdominal B-ultrasound and the clinical curative efficacy of TCM syndrome in the observation group were better than those in the control group(P＜0.05).Conclusions:The combination of Qinghua Formula and lifestyle interventions can help improve liver fat deposition in NAFLD patients and relieve their TCM symptoms,with definite clinical curative efficacy.
non-alcoholic fatty liver diseaseQinghua Formuladampness-heatglucolipid metabolismcontrolled attenuation parametertraditional Chinese medicine syndrome
万方数据
维普
