单纯中药延长腹膜后恶性肿瘤无进展生存期个案报道

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中文摘要：报道单纯中药延长腹膜后恶性肿瘤无进展生存期验案1则。患者因糖类抗原125(CA125)升高，发现腹膜后占位，病理确诊为原发性腹膜后高级别浆液性癌，先后行4周期白蛋白紫杉醇联合卡铂化疗，序贯2周期单药白蛋白紫杉醇化疗，治疗后CA125降至正常，腹膜后占位缩小，疗效评价为部分缓解。之后患者拒绝化疗、手术或靶向治疗，要求纯中药治疗。第一阶段治以益气养血、活血化瘀为主，治疗后骨髓抑制及周围神经毒性等症状减轻。第二阶段治以攻补兼施，予龙蛇羊泉汤加益气养血之品。第三阶段正气已复，治疗以攻毒抗癌为主，予平肝消燚方。单纯中药维持治疗在提高患者生活质量的基础上，有效地控制肿瘤复发转移，患者获得28个月无进展生存期，且肿瘤呈持续缓慢缩小。

外文标题：A Case Study on Solely Using Chinese Medicine to Extend Progression-Free Survival in a Patient with Retroperitoneal Malignant Tumor

外文摘要：A case of extending the progression-free survival of retroperitoneal malignant tumor with Chinese medicine was reported.The patient was diagnosed with primary retroperitoneal high-grade serous carcinoma due to an elevated CA125 level and a retroperitoneal space-occupying lesion.Four cycles of paclitaxel albumin combined with carboplatin chemotherapy were administered,followed by two cycles of single-agent albumin-paclitaxel chemotherapy.After treatment,CA125 decreased to normal level and the retroperitoneal mass shrunk.The therapeutic effect was evaluated as partial relief.After that,the patient refused chemotherapy,surgery,or targeted therapy and requested pure Chinese medicine treatment.In the first stage,the treatment focused on supplementing qi and nourishing blood,promoting blood circulation and removing blood stasis.After treatment,symptoms such as bone marrow suppression and peripheral neurotoxicity caused by chemotherapy were alleviated.In the second stage,the treatment focused on both attacking pathogenic factors and supplementing healthy qi,Longshe Yang-quan Decoction(龙蛇羊泉汤)was administered with additional ingredients to benefit qi and nourish blood.In the third stage,the healthy qi had been restored,and the treatment focused on attacking toxins and fighting cancer,with Pinggan Xiaoyi Formula(平肝消燚方)as the primary prescription.By solely using Chinese medicine for maintenance treatment,the tumor recurrence and metastasis were effectively controlled and the life quality of the patient was improved.The patient achieved a progression-free survival period of 28 months,with the tumor continuously shrinking slowly.

外文关键词：

solely using traditional Chinese medicine for maintenance treatmentretroperitoneal malignant tumorShengxue Decoction(升血汤)Longshe Yangquan DecoctionPinggan Xiaoyi Formulaprogression-free survival

作者：

念家云、富琦、王笑民

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作者单位：

首都医科大学附属北京中医医院肿瘤科,北京 100010

关键词：

单纯中药维持治疗腹膜后恶性肿瘤升血汤龙蛇羊泉汤平肝消燚方无进展生存期

基金：

国家自然科学基金青年科学基金北京市市属医院科研培育项目

项目编号：

82305342PZ2023010

出版年：

2024

DOI：

10.16295/j.cnki.0257-358x.2024.06.018

山东中医杂志

山东中医药学会山东中医药大学

山东中医杂志

CSTPCD

影响因子：0.431

ISSN：0257-358X

年,卷(期)：2024.43(6)