Model-Based Evaluation of Constipation of Qi and Blood Deficiency Type and Efficacy Analysis of Modified Buzhong Yiqi Decoction(补中益气汤)in Its Treatment
Objective:To analyze the influencing factors for constipation of qi and blood deficiency type,and to evaluate the efficacy of modified Buzhong Yiqi Decoction(补中益气汤)in its treatment.Methods:A total of 194 patients with constipation of blood and qi deficiency type were included in this study.Among them,103 patients were treated with modified Buzhong Yiqi Decoction,and 91 patients were treated with lactulose oral solution.Principal component factor analysis and cluster analysis were performed using Matlab 2018B software to analyze the constipation of qi and blood deficiency type.The independent factors affecting the clinical efficacy of constipation were analyzed using univariate and multivariate Logistic regression analysis.Results:After principal component factor analysis and cluster analysis,patients in this study were clustered into three categories in which SIL=0.723 indicating a good clustering quality.The first category was of the highest recovery rate(P＜0.05)and of the highest total effective rate(P＜0.05),while the third category was of the lowest recovery rate(P＜0.05)and of the lowest total effective rate(P＜0.05).The first category was of significantly lower levels of interleukin-6(IL-6)and C-reactive protein(CRP)compared to the second and the third categories,and of a significantly higher proportion of patients treated with modified Buzhong Yiqi Decoction compared to the second and the third categories(P＜0.05).The second category was of significantly lower level of CRP compared to the third category,and of a significantly higher proportion of patients treated with modified Buzhong Yiqi Decoction compared to the third category(P＜0.05).The first and second categories was of significantly lower Patient Assessment of Constipation Quality of Life(PAC-QOL)scores compared to the third category(P＜0.05).The first category was of significantly lower traditional Chinese medicine(TCM)syndrome scores compared to the second and third categories(P＜0.05).High levels of IL-6 and CRP,and high PAC-QOL and TCM syndrome scores were identified as independent risk factors for.prognosing no effect.Conclusions:Based on the multi-factor regression model,high levels of IL-6 and CRP,and high PAC-QOL and TCM syndrome scores were found to be independent risk factors for prognosing no effect,while the modified Buzhong Yiqi Decoction treatment was a protective factor.
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