Effect of Bushen Shugan Sanjie Decoction(补肾疏肝散结汤)on Breast Hyperplasia and Serum Sex Hormone Level
Objective:To investigate the curative effect of Bushen Shugan Sanjie Decoction(补肾疏肝散结汤)on patients with breast hyperplasia and its effect on serum sex hormone level.Methods:The study subjects were 90 patients with breast hyperplasia who were diagnosed and treated from July 2020 to August 2022.And they are randomly divided into two groups of 45 cases each.The control group was treated with tamoxifen citrate tablets,and the observation group was treated with Bushen Shugan Sanjie Decoction for 3 consecutive menstrual cycles.Traditional Chinese medicine(TCM)syndrome score(breast mass,breast pain,nipple discharge,and other accompanying symptoms),breast ultrasound index,serum sex hormone[progesterone(P),prolactin(PRL),estradiol(E2)]levels,and disease recurrence rate at 3 and 6 months after treatment were observed in the two groups before and after treatment,and the total clinical effective rate and treatment safety were compared between the two groups.Results:After treatment,TCM syndrome score,breast ultrasound indicators,PRL and E2 levels were all decreased in both groups(P＜0.05),and the observation group was lower than the control group(P＜0.05).The P indexes of both groups were increased(P＜0.05),and the observation group was higher than the control group(P＜0.05).The recurrence rate of the observation group was lower than that of the control group(P＜0.05).The total effective rate of the observation group was higher than that of the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups(P＞0.05).Conclusions:Bushen Shugan Sanjie Decoction has a significant effect in the treatment of breast hyperplasia,which can effectively relieve breast pain and other discomfort symptoms,regulate serum sex hormone levels,improve breast ultrasound indicators,reduce the recurrence rate of disease,and have fewer adverse reactions.
breast hyperplasiaBushen Shugan Sanjie Decoctionsex hormonebreast ultrasound indicatorssyndrome of liver depression and kidney deficiencyrecurrence rate
万方数据
维普
