Clinical Observation of Bushen Yifei Decoction(补肾益肺方)in Treating Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis
Objective:To observe the curative effect of Bushen Yifei Decoction(补肾益肺方)in treating chronic obstructive pulmonary disease(COPD)of lung-kidney deficiency syndrome in stable stage complicated with osteoporosis.Methods:A total of 128 patients with COPD complicated with osteoporosis were divided into the observation group and the control group with random number table method,with 64 patients in each group.Finally,122 patients completed the study,with 62 patients in the observation group and 60 patients in the control group.On the basis of basic treatment,the control group was treated with Chinese medicine placebo,and the observation group was treated with Bushen Yifei Decoction.After 3 months of treatment,the number of acute exacerbations,traditional Chinese medicine(TCM)syndrome scores,COPD patient self-assessment test(CAT)scores,bone mineral density,lung function[forced expiratory volume at 1 second(FEV1),percentage of forced expiratory volume at 1 second to expected value(FEV1％),percentage of forced expiratory volume at 1 second to forced vital capacity(FEV1/FVC)],6-minute walking distance(6MWD),visual analogue scale(VAS)score for osteoporotic bone pain,bone metabolism biochemical markers[N-terminal peptide of type Ⅰ collagen(PINP),serum β Gel degradation products(β-CTX)and 25-hydroxyvitamin D(25-OH-VD)]were observed in the two groups.Results:The number of acute exacerbations in the observation group was less than that in the control group(P＜0.05).After treatment,TCM syndrome score and CAT score of both groups were decreased,and the observation group was lower than the control group(P＜0.05).The levels of pulmonary function indexes in both groups were increased,and FEV1 and FEV1％in the observation group were higher than those in the control group(P＜0.05).6MWD in both groups was longer than that before treatment,and 6MWD in the observation group was longer than that in control group(P＜0.05).VAS score in the observation group was lower than that before treatment,and lower than that in the control group after treatment(P＜0.05).The level of β-CTX in both groups was lower than that before treatment,and the observation group was lower than the control group(P＜0.05).The levels of PINP and 25-OH-VD in both groups were higher than those before treatment,and the observation group was higher than the control group(P＜0.05).During drug treatment,neither group experienced any serious adverse reactions.Conclusion:Bushen Yifei Decoction can significantly reduce the number of acute exacerbations,relieve clinical symptoms,improve lung function indicators and bone metabolism level in treating COPD complicated with osteoporosis.
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