Study on Effect of Du-Moxibustion on Patients with Airway Hyperresponsiveness
Objective:To investigate the effects of Du-moxibustion on inflammation level,intestinal flora and quality of life in patients with airway hyperresponsiveness(AHR).Methods:A self-controlled before and after trial was conducted in 30 patients with AHR,the intervention of Du-moxibustion was given.The levels of inflammatory factors[interleukin-4(IL-4),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α)],intestinal flora structure,abundance,diversity,characteristics and quality of life[assessed by applying St.George's Respiratory Questionnaire(SGRQ)]of the patients were observed.Results:The levels of IL-4,IL-17,TNF-α,Sorensen index,and abundances of Bacteroides in AHR patients receiving Du-moxi-bustion intervention for 4 weeks were improved,which were with statistically significant differences(P＜0.05).The key bacteria of the patients before Du-moxibustion intervention were Vibrio desulphuricoides,Bacteroides monoformis,Gram-positive bacteria,Holderia filamenti,Lactococcus grigeri,Lactobacillus lactobacilli,Bacillus formicum,Prevotella,Roche,Lactococcus lactis and S24_7 bacteria.The key bacteria after Du-moxibustion intervention were Doleria,Rumenococcus limeniae,Rhizobacteria mosieri,Serratia,Veillonella variabilis,Clostridium lavandulae,Clostridium spiralis,Clostridium aldendii and Staphylococcus sciuris.The SGRQ scores of AHR patients after Du-moxibustion intervention were significantly lower than those before the intervention,and the difference was statistically significant(P＜0.05).Conclusion:Du-moxibustion intervention can relieve the clinical symptoms and improve the quality of life in patients with AHR,and its mechanism may be related to inhibiting inflammation and regulating intestinal flora.
Du-moxibustionairway hyperresponsivenessintestinal florainflammationquality of life
万方数据
维普
