首页|从肿瘤微环境探讨"痞坚之处,必有伏阳"

从肿瘤微环境探讨"痞坚之处,必有伏阳"

扫码查看
"痞坚之处,必有伏阳"出自《金匮要略心典》,近年来被广泛应用于肿瘤领域。多数医家认为,在肿瘤的发生发展中,"痞坚为因,伏阳为果",并以此解释肿瘤阻滞气机、郁闭阳气而导致癌性发热、癌性疼痛及放疗、化疗后不良反应的机制。笔者基于西医的肿瘤微环境学说,提出"伏阳为因、痞坚为果"的新观点,认为伏阳作为始动因素,通过诱发氧化应激、激活免疫逃逸、升高间质液压、释放炎症介质形成肿瘤代谢微环境、免疫微环境、高压微环境和炎症微环境,最终导致肿瘤的发生。因此,临床可采用清透壅滞伏阳、补散中焦伏阳之法达到逆转肿瘤微环境、抑制肿瘤发生的目的。
Discussion on "There Must Be Latent Yang Where There Are Fullness and Stasis" from Perspective of Tumor Microenvironment
"There must be latent yang where there are fullness and stasis"comes from The Essence of Synopsis of Golden Chamber and it has been widely used in the field of cancer in recent years.Most doctors believe that"fullness and stasis are the causes and latent yang is the result"in the occurrence and development of tumors,explaining the mechanism through which tumors obstruct qi movement and stagnate yang qi,leading to carcinogenic fever,cancerous pain,and adverse reactions after radiotherapy and chemo-therapy.Based on the theory of tumor microenvironment in western medicine,the author puts forward a new view of"latent yang is the cause,and fullness and stasis are the results",and believes that latent yang,as the initial factor,induces oxidative stress,activates immune escape,elevates interstitial hydraulic pressure,and releases inflammatory mediators to form tumor metabolic microenvironment,immune microenvironment,high-pressure microenvironment and inflammatory microenvironment,which ultimately leads to the occurrence of tumor.Therefore,the method of clearing obstructed latent yang and replenishing latent yang in the middle jiao can be used to reverse tumor microenvironment and inhibit tumor occurrence.

There must be latent yang where there are fullness and stasistumor microenvironmentoxidative stressimmune escapeinterstitial high pressureinflammationdispersing fire in treating fire stagnation

熊宏泰、蔡柳、郑红刚

展开 >

中国中医科学院广安门医院肿瘤科,北京 100053

痞坚之处,必有伏阳 肿瘤微环境 氧化应激 免疫逃逸 间质高压 炎症 火郁发之

国家自然科学基金面上项目

82174463

2024

山东中医杂志
山东中医药学会 山东中医药大学

山东中医杂志

CSTPCD
影响因子:0.431
ISSN:0257-358X
年,卷(期):2024.43(10)