Meta-Analysis of Curative Efficacy of Traditional Chinese Medicine in Treating Tumor-Related Anxiety and Depression and Its Impact on Immune Level of Patients
Objective:To conduct a scientific and systematic evaluation on the clinical curative efficacy of traditional Chinese medicine in the treatment of tumor-related anxiety and depression and its effect on the immune level of patients,so as to provide evidence-based reference for the clinical treatment of tumor-related anxiety and depression.Methods:Randomized controlled trials(RCTs)on the treatment of tumour-related anxiety and depression with traditional Chinese medicine which detecting relevant immune indicators of the patients were retrieved from databases including CNKI,Wanfang,VIP,PubMed,Cochrane,Embase databases,etc.from their establishment to February 2024.RevMan 5.4.1 software was used for literature quality evaluation and data statistics.Results:A total of 17 RCTs were included,including 1531 patients(798 patients in the experimental group and 733 patients in the control group).Patients in the control group received conventional anti-cancer treatment,with or without the addition of western medicine anti-anxiety,anti-depression therapy.The experimental group received traditional Chinese medicine treatment on the basis of western medicine treatment.Meta-analysis results showed that the total effective rate of clinical treatment for depression in the experimental group[OR=2.49,95％CI(1.36,4.56),P＜0.05]was higher than that in the control group,and the Hamilton Depression Scale(HAMD)score[MD=-1.62,95％CI(-1.81,-1.42),P＜0.000 01],Self-rating Depression Scale(SDS)score[MD=-15.18,95％CI(-15.75,-14.60),P＜0.000 01],Hamilton Anxiety Scale(HAMA)score[MD=-4.32,95％CI(-5.90,-2.73),P＜0.000 01],the score of Self-rating Anxiety Scale(SAS)[MD=-15.12,95％CI(-16.47,-13.76),P＜0.000 01]of the experimental group were lower than those of the control group,and the levels of immune-related index CD3+[MD=8.17,95％CI(5.87,10.47),P＜0.000 01],CD4+[MD=7.05,95％CI(4.92,9.18),P＜0.000 01],NK cell[OR=3.38,95％CI(2.58,4.19),P＜0.000 01]of the experimental group were higher than those of the control group.The CD8+level of the experimental group was lower than that of the control group[MD=-2.11,95％CI(-3.90,-0.31),P=0.02],and the difference was statistically significant.Conclusions:Traditional Chinese medicine is effective in the treatment of tumor-related anxiety and depression,and it can enhance the immune level of the patients,improve the psychological state and quality of life of the patients,and has good safety.
traditional Chinese medicinetumor-related anxietytumor-related depressionimmune levelMeta-analysis
万方数据
维普
