Objective:To observe the curative efficacy of moxibustion therapy on gastrointestinal dysfunction in peritoneal dialysis patients with spleen and kidney yang deficiency type,and explore the related mechanisms.Methods:A total of 72 peritoneal dialysis patients with gastrointestinal dysfunction(spleen and kidney yang deficiency type)were randomly divided into the control group and the moxibustion group,with 36 patients in each group.In the end,69 patients completed the study,including 35 in the control group and 34 in the moxibustion group.The patients in both groups received conventional basic treatment in western medicine,supplemented with moxibustion at Zusanli(ST36)and Sanyinjiao(SP6)acupoints for the moxibustion group.The two groups were treated for three courses,with each course lasting 4 weeks.Comparisons were made between the two groups in the scores of the Gastrointestinal Symptom Rating Scale(GSRS),Subjective Global Assessment(SGA),and levels of serum gastrin(GAS),motilin(MOT),and cholecystokinin(CCK)before and after treatment.The curative efficacy for gastrointestinal symptoms was evaluated in both groups.Results:After treatment,the GSRS score and serum levels of GAS,MOT,and CCK in both groups were lower than those before treament(P＜0.01),and the SGA score in both groups was higher than that before treament(P＜0.01).After treatment,the GSRS score in the moxibustion group was lower than that in the control group(P＜0.01),while the SGA score was higher.The serum levels of GAS,MOT,and CCK were also lower in the moxibustion group compared to those in the control group.All the above differences were statistically significant(P＜0.05).The total effective rate of gastrointestinal symptoms in the moxibustion group was higher than that in the control group,and there was a statistically significant difference between the two groups in terms of curative efficacy on gastrointestinal symptoms(P＜0.05).Conclusions:Moxibustion therapy can alleviate gastrointestinal symptoms and improve nutritional status in peritoneal dialysis patients with gastrointestinal dysfunction(spleen and kidney yang deficiency type).Its mechanisms may be related to the regulation of serum levels of GAS,MOT,and CCK.
关键词
艾灸/腹膜透析/胃肠功能/胃肠道症状分级量表/主观整体营养评估/胃肠激素
Key words
moxibustion/peritoneal dialysis/gastrointestinal function/Gastrointestinal Symptom Rating Scale(GSRS)/Subjective Global Assessment(SGA)/gastrointestinal hormones
维普
万方数据