The Influence of Exercise on Vasoconstrictive Function in Insulin Resistant Rats in Hypoxic Environment
In order to investigate the effect of exercise on vasoconstrictive function in insulin resistant body in hypoxic environment,the normal diet rats were set up normal oxygen quiet control group(NN),insulin resistant SD rats were divided into normal oxygen quiet group(NC),hypoxia quiet group(HC),normal oxygen exercise group(NE)and intermittent hypoxia exercise group(HE).During the intervention period,high-fat diet,hypoxic environment regimen was 4h per day,O2 concentration was 14.5％,and exercise regimen was treadmill exercise for 1h at a speed of 25m/min and 5d/W.After 4 weeks of intervention,the level of angiotensin Ⅱ in HC and NE groups was lower than that in NC group(P＜0.01),and the level of angiotensin Ⅱ in HE group was higher than that in HC group(P＜0.05).Compared with NC group,NO levels in the other 3 groups were higher(P＜0.01),as NE＜HE＜HC(P＜0.01);the levels of T-NOS and iNOS in the other 3 groups were lower than those in the NC group(P＜0.01).Compared with HC group,the levels of iNOS in NE group were lower(P＜0.01),and the levels of T-NOS and iNOS in HE group were lower(P＜0.05).The iNOS level in HE group was lower than that in NE group(P＜0.01).A 4 weeks of intermittent hypoxic environment and/or moderate exercise stimulation can regulate vasoconstriction function in insulin-resistant rats with high fat diet by affecting angiotensin Ⅱ and NO levels.
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