肥胖2型糖尿病患者治疗前后apelin和TNF-α水平变化及其意义
Significance of Apelin and TNF-α level changes in obese patients with type 2 diabetes mellitus before and after treatment
徐华 1侯为开 1张莉 2朱蕾 2娄福臣 1张莹 1王倩 1于姗1
作者信息
- 1. 山东大学齐鲁医院内分泌科,济南250012
- 2. 山东交通医院内科,济南250031
- 折叠
摘要
目的 探讨初诊肥胖2型糖尿病(T2DM)患者治疗前后血清Apelin与肿瘤坏死因子-α(TNF-α)水平变化及其意义.方法 收集初诊肥胖T2DM患者(T2DM组,n=61),随机接受二甲双胍(Met组,n=31)和罗格列酮(Rog组,n=30)治疗,健康体检者为正常对照组(NC组,n=30).检测治疗前后血清Apelin、TNF-α、空腹血糖(FBG)、空腹胰岛素(FIN)、糖化血红蛋白(HbA1c)水平及体质量指数(BMI)的变化,以稳态模型计算胰岛素抵抗指数(HOMA-IR).结果 肥胖T2DM患者Apelin、TNF-α水平均显著高于NC组(P均<0.05),且与BMI、HN、FBG、HOMA-IR均呈正相关(P均<0.05);治疗后Apclin、TNF-α、FBG、HbA1c水平均显著下降(P均<0.05),其中Rog组Apelin、TNF-α水平较Met组下降更为显著(P<0.05),Met组BMI显著下降(P<0.05),Rog组无显著变化(P>0.05);相关分析显示治疗前后Apelin与TNF-α均密切相关(P均<0.05).结论 肥胖T2DM患者血清高水平Apelin、TNF-α可能参与胰岛索抵抗的发生发展过程.
Abstract
Objective To investigate the effects of treatment with insulin-sensitizing agents on serum Apelin and tumor necrosis factor-α (TNF-α) levels in obese patients with type 2 diabetes mellitus(T2DM), and to assess the significance of Apelin and TNF-α level changes. Methods 61 newly-diagnosed obese patients with T2DM were enrolled in this study, and they were randomly divided to receive either metformin(the Met group, n = 31) or rosiglitazone (the Rog group, n=30) treatment. 30 healthy individuals were included as the normal control group(NC group, n =31). Serum Apelin, TNF-α, fasting blood glucose (FBG), fasting insulin (FIN), glycosylated hemoglobin (HbA1c) and body mass index (BMI) were measured before and after treatment. The insulin resistance index (HOMA-IR) was assessed by a homeostasis model (HOMA). Results Both serum Apelin and TNF-α levels in obese patients with T2DM were significantly higher than those in the control group, and they were positively correlated with BMI, FIN, FBG and HOMA-IR(P<0.05). Apelin, TNF-α,FBG and HbAlc significantly decreased after treatment compared to those before treatment(P<0.05). Moreover, the Rog group showed lower Apelin and TNF-α levels than those in the Met group (P<0.05). BMI was significantly decreased in the Met group(P<0.05) . But had no significant change(P>0.05) in the Rog group. Apelin level was positively correlated with TNF-α both before treatment (P<0.05) and after treatment (P<0.05). Conclusion High levels of serumApelin and TNF-α in obese patients with T2DM may be involved in the occurrence and development of insulin resistance.
关键词
2型糖尿病/肥胖/Apelin/肿瘤坏死因子-αKey words
Type 2 diabetes mellitus/Obesity/Apelin/Tumor necrosis factor-α引用本文复制引用
出版年
2010
NETL
NSTL
维普
万方数据