SPECT/CT融合骨显像诊断肺癌单发骨转移的价值
Validity of SPECT/CT bone fusing imaging in the diagnosis of single bone metastasis of lung cancer
王善容 1丁月云 1朱宗平 1石德道 1刘晚霞 1郑飞波1
作者信息
- 1. 青岛大学附属青岛市立医院核医学科,山东青岛266071
- 折叠
摘要
目的 探讨单光子发射计算机断层成像技术/电子计算机X射线断层扫描技术(SPECT/CT)融合骨显像在诊断肺癌单发骨转移中的价值.方法 回顾性分析2014年6月至2015年6月行全身骨显像并对单发可疑病灶行SPECT/CT断层融合显像进一步检查的肺癌患者80例,分别统计两种方法的诊断结果,并与最终结果对照.病理确定3例,由2种以上影像技术结果确定45例,随访结果确定32例.计算两者灵敏度、特异性、准确性、阳性预测值、阴性预测值.采用SPSS 17.0统计学软件,x2检验比较全身骨显像与SPECT/CT融合骨显像的诊断结果.结果 全身骨显像和SPECT/CT断层融合显像对肺癌骨转移的诊断效能分别是:特异性58.3％ vs 91.7％(x2=10.67,P＜0.05),准确性71.3％ vs 90.0％(x2=9.002,P＜0.05),阳性预测值70.6％ vs 92.9％(x2=7.318,P＜0.05),灵敏度81.8％ vs 88.6％(x2 =0.81,P＞0.05),阴性预测值72.4％ vs 86.8％(x2 =0.81,P＞0.05).结论 SPECT/CT断层融合显像诊断肺癌单发骨转移的特异性、准确性、阳性预测值优于全身骨显像.SPECT/CT融合骨显像诊断肺癌单发骨转移具有重要价值.
Abstract
Objective To investigate the validity of single-photon emission computed tomography/computed tomography (SPECT/CT) bone fusing imaging in the diagnosis of single bone metastasis of lung cancer.Methods A retrospective study was conducted during June 2014 and June 2015 on 80 patients with confirmed lung cancer.All patients underwent 99Tc-methylene diphosphonate whole-body planar bone scintigraphy and had suspected bone metastasis.These patients were then further evaluated with SPECT/CT.The diagnostic results of the two methods were compared.The final results were confirmed with pathology findings (n =3),with more than 2 kinds of radiological imaging findings (n =45),and with 1-year follow-up (n =32).The diagnostic sensitivity,specificity,accuracy,positive and negative predictive values of the two methods were compared.The results were analyzed with SPSS 17.0 software and x2 test.Results For bone scintigraphy and SPECT/CT fusion imaging,the specificity was 58.3％ vs 91.7％ (x2=10.67,P＜ 0.05),accuracy was 71.3％ vs 90.0％ (x2 =9.002,P＜0.05),positive predictive value was 70.6％ vs 92.9％ (x2 =7.318,P＜0.05),sensitivity was 81.8％ vs 88.6％ (x2 =0.81,P＞0.05),and the negative predictive value was 72.4％ vs 86.8％ (x2 =0.81,P＞0.05).Conclusion In the diagnosis of single bone metastasis of lung cancer,the SPECT/CT bone fusion imaging was superior to whole-body planar bone scintigraphy for its specificity,accuracy and positive predictive value.SPECT/CT fusion bone imaging is of great value in the diagnosis of single bone metastasis of lung cancer.
关键词
单光子发射计算机断层成像技术/电子计算机X射线断层扫描技术/全身平面骨显像/肺癌/骨转移/诊断Key words
Single-photon emission computed tomography/computed tomography/Whole bone scintigraphy/Lung cancer/Bone metastasis/Diagnosis引用本文复制引用
基金项目
青岛市科技局民生科技计划(14-2-3-22-nsh)
国家自然科学基金(81601524)
出版年
2018
NETL
NSTL
维普
万方数据