胆固醇代谢在骨关节炎疾病中的作用及研究进展
Role of cholesterol metabolism in osteoarthritis:a review of research progresses
赵智博 1满振涛 2李伟1
作者信息
- 1. 山东大学齐鲁医学院,山东 济南 250012;山东第一医科大学附属省立医院关节外科,山东 济南 250021
- 2. 山东第一医科大学附属省立医院关节外科,山东 济南 250021
- 折叠
摘要
骨关节炎(osteoarthritis,OA)是一种与年龄相关的退行性疾病,长期以来一直与肥胖有关.有研究指出OA可能是一种代谢性疾病,因为它不仅累及负重关节也累及非负重关节.新出现的证据表明OA中存在着异常的胆固醇代谢.异常的胆固醇代谢途径会伴随着产生一些促炎物质,这些物质对OA的发展至关重要.因此调节胆固醇异常代谢的药物可能在OA中具有巨大的治疗前景.现着重总结了胆固醇代谢在OA疾病中的作用和综合分子机制,提出多角度调控胆固醇代谢可能是临床治疗OA疾病的一种有前景的策略.
Abstract
Osteoarthritis(OA)is a degenerative disease associated with aging and has long been linked to obesity.Some studies suggest that OA might be a metabolic disease,impacting not only weight-bearing joints but also non-weight-bearing joints.Emerging evidence indicates abnormal cholesterol metabolism in osteoarthritis,with pathways leading to the production of pro-inflammatory substances crucial to OA development.Drugs capable of modulating ab-normal cholesterol metabolism hold considerable therapeutic promise for OA.This article aims to summarize the role and comprehensive molecular mechanisms of cholesterol metabolism in osteoarthritis and proposes that a multi-faceted regu-lation of cholesterol metabolism could be a promising strategy for the clinical treatment of osteoarthritis.
关键词
骨关节炎/代谢综合征/胆固醇代谢异常/氧化修饰低密度脂蛋白/胆固醇代谢Key words
Osteoarthritis/Metabolic syndrome(MetS)/Cholesterol metabolism disorder/Oxidized low density lipo-protein/Cholesterol metabolism引用本文复制引用
基金项目
山东省重点研发计划(2020CXGC010502)
出版年
2024
NETL
NSTL
万方数据