Effects of intense pulsed light on the meibomian gland and tear film lipid layer in patients with lipid deficiency dry eye disease
Objective To observe the effects of intense pulsed light(IPL)on the meibomian gland and tear film lipid layer in patients with lipid deficiency dry eye disease.Methods A total of 60 patients(120 eyes)with lipid deficiency dry eye disease were divided into control group(60 eyes)and IPL group(60 eyes)using random numbers.Before and after 6 weeks of treatment,non-invasive breakup time(NIBUT),ocular surface disease index(OSDI)questionnaire,and corneal fluorescein staining(CFS)were assessed to evaluate the indicators of dry eye disease.The Oculus Kerato-graph analyzer and meibomian gland evaluator(MGE)were used to determine the meibomian gland dropout score(MGDS),meibomian gland yielding liquid secretion(MGLYS)and meibomian gland yielding secretion score(MGYSS)to assess the meibomian gland.The LipiView interferometer was used to evaluate the tear film lipid layer thickness(LLT).Results No statistically significant differences were observed between the two groups before treat-ment.Compared with baseline,NIBUT,OSDI,CFS,MGLYS,MGYSS and LLT were improved in both groups after treatment(all P<0.001),while there was no significant difference in MGDS.Except MGDS,the other parameters in the IPL group were improved better than those in control group after treatment(PNIBUT=0.031,POSDI=0.023,PCFS=0.014,PMGLYS=0.020,PMGLYS=0.023,PLLT=0.004).No adverse reactions occurred during the treatment.Conclusion IPL could improve the function of meibomian gland and the thickness of tear film lipid layer;it is an effective and safe treatment for patients with lipid deficiency dry eye disease.
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