Research progress on biological and cellular therapies for severe asthma
Asthma is a highly heterogeneous disease with multiple effector cells and cytokines involved in its develop-ment.In severe asthma,conventional high-dose inhaled glucocorticoid therapy is usually difficult to control symptoms,and patients may present with persistent airflow limitation and worsening symptoms,leading to decreased quality of life and increased healthcare burden.Currently,the exploration of biological therapies targeting effector cells or cytokines offers novel treatment options as add-on therapies for severe asthma.In recent years,studies have also pioneered the application of novel cellular therapies,such as stem cell therapy or chimeric antigen receptor T(CAR-T)cell therapy,to the treatment of severe asthma.In this article,we will review the research progress of biological agents for severe asthma and novel cellular therapies as potential therapeutic strategies,describe promising biological therapies and their mechanisms of action,efficacy and safety,and on the basis of which,we will look forward to the future development of biological and cellular therapies as a strategy for the treatment of severe asthma in terms of long-term efficacy and safety,precision medicine,patient accessibility,and interdisciplinary cooperation.
Severe asthmaBiological therapyCellular therapyMonoclonal antibodyStem cell therapyCAR-T cell therapy
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