Mendelian randomization study of visceral adipose tissue and lung diseases
Objective To investigate the causal relationship between obesity and lung diseases using Mendelian randomi-zation(MR)methodology.Methods Employing the inverse variance weighted(IVW)method in conjunction with six distinct MR methodologies,and utilizing summary data from genome-wide association studies(GWAS),the causal rela-tionships between visceral adipose tissue(VAT)and lung diseases,including chronic obstructive pulmonary disease,sleep apnea,lung cancer,pneumonia,pulmonary embolism,idiopathic pulmonary fibrosis and tuberculosis,were assessed.Sensitivity analysis was performed using the leave-one-out method,Cochran's Q test,MR-Egger regression intercept term test,and MR-PRESSO test to evaluate the heterogeneity,pleiotropy,and stability of the instrumental varia-bles.Results The results of the IVW method indicated that genetically predicted higher VAT was causally associated with higher occurrence risks of chronic obstructive pulmonary disease(OR=1.56,95％CI:1.33-1.84,P＜0.001),sleep apnea(OR=1.76,95％CI:1.53-2.03,P＜0.001),lung cancer(OR=1.39,95％CI:1.23-1.58,P＜0.001),and pneumonia(OR=1.22,95％CI:1.15-1.30,P＜0.001).Except for MR-Egger,the results of the other four MR methods were consistent with the main analysis results.In addition,there was evidence suggested that higher VAT would increase the occurrence risks of pulmonary embolism(OR=1.18,95％CI:1.04-1.34,P=0.009)and idiopathic pulmonary fibrosis(OR=1.00,95％CI:1.00-1.00,P=0.011).Conclusion VAT accumulation may increase the occurrence risks of chronic obstructive pulmona-ry disease,sleep apnea,lung cancer,pneumonia,pulmonary embolism and idiopathic pulmonary fibrosis.
NETL
NSTL
万方数据
