Mendelian randomization analysis of causality between dietary factors and preeclampsia
Objective To explore the potential causal link between dietary factors and preeclampsia.Methods By leveraging Genome-wide association studies(GWAS)data,Mendelian randomization(MR)analyses were employed utilizing Inverse-variance weighted(IVW),Weighted median(WM),and MR-Egger regression techniques to assess the causal association between dietary factors and preeclampsia.Furthermore,heterogeneity tests,sensitivity analyses,and pleiotropy assessments to were conducted ensure the robustness of the findings.Results The analysis revealed a negative causal relationship between preeclampsia and the consumption of cheese(IVW:OR＝0.504,95%CI:0.314-0.808,P＝0.004)as well as salads/raw vegetables(IVW:OR＝0.195,95%CI:0.041-0.923,P＝0.039).All results demonstrated an absence of pleiotropic effects,and the leave-one-out approach further validated the robustness of the findings.No causal associations were observed between preeclampsia and other dietary factors examined.Conclusion A reduced risk of preeclampsia associated with cheese intake and the consumption of salads/raw vegeta-bles is identified in European populations.However,confirmation of these relationships and exploration of the underly-ing mechanisms require validation using larger GWAS datasets.Additionally,no causal links are established between preeclampsia and the remaining dietary factors investigated.
NETL
NSTL
万方数据
