饮食因素与子痫前期因果关系的孟德尔随机化分析
Mendelian randomization analysis of causality between dietary factors and preeclampsia
张展 1李建锋 1李燕玲 1王博雯 1昂文成林龙珠 2王鑫 3张小明 3谢萍1
作者信息
- 1. 甘肃省人民医院心血管内科
- 2. 兰州大学第一临床医学院,甘肃 兰州 730000
- 3. 甘肃中医药大学第一临床医学院
- 折叠
摘要
目的 探讨饮食因素与子痫前期的可能因果效应.方法 利用全基因组关联研究(genome-wide association studies,GWAS)数据,采用逆方差加权法(inverse-variance weighted,IVW)、加权中位数(weighted median,WM)、MR Egger回归(MR-Egger regression)进行孟德尔随机化(Mendelian randomization,MR)分析,评估饮食因素与子痫前期的因果关系.并且,进行异质性检验、敏感性分析、多效性分析.结果 奶酪摄入量(IVW:OR＝0.504,95%CI:0.314~0.808,P＝0.004)、沙拉/生蔬菜摄入量(IVW:OR＝0.195,95%CI:0.041~0.923,P＝0.039)与子痫前期存在负向因果关系.且所有结果均不存在多效性,留一法亦提示所得结果稳健.其他饮食因素未发现与子痫前期具有因果关系.结论 这项双样本MR分析发现奶酪摄入量、沙拉/生蔬菜摄入量与欧洲人群子痫前期风险降低有关,但仍需更大的GWAS数据进一步验证这种关系,同时研究其中潜在关联机制,以支持该结论.此外,其他饮食因素未发现与子痫前期具有因果关系.
Abstract
Objective To explore the potential causal link between dietary factors and preeclampsia.Methods By leveraging Genome-wide association studies(GWAS)data,Mendelian randomization(MR)analyses were employed utilizing Inverse-variance weighted(IVW),Weighted median(WM),and MR-Egger regression techniques to assess the causal association between dietary factors and preeclampsia.Furthermore,heterogeneity tests,sensitivity analyses,and pleiotropy assessments to were conducted ensure the robustness of the findings.Results The analysis revealed a negative causal relationship between preeclampsia and the consumption of cheese(IVW:OR＝0.504,95%CI:0.314-0.808,P＝0.004)as well as salads/raw vegetables(IVW:OR＝0.195,95%CI:0.041-0.923,P＝0.039).All results demonstrated an absence of pleiotropic effects,and the leave-one-out approach further validated the robustness of the findings.No causal associations were observed between preeclampsia and other dietary factors examined.Conclusion A reduced risk of preeclampsia associated with cheese intake and the consumption of salads/raw vegeta-bles is identified in European populations.However,confirmation of these relationships and exploration of the underly-ing mechanisms require validation using larger GWAS datasets.Additionally,no causal links are established between preeclampsia and the remaining dietary factors investigated.
关键词
饮食/奶酪/蔬菜/子痫前期/孟德尔随机化Key words
Diet/Cheese/Vegetable/Preeclampsia/Mendelian randomization引用本文复制引用
基金项目
甘肃省国际科技合作项目(20YF3WA011)
兰州市人才创新创业项目(2018-RC-72)
甘肃省中医药科研项目(GZKZ-2021-7)
甘肃省人民医院优秀博士生培育计划(22GSSYD-14)
出版年
2024
NETL
NSTL
万方数据