Progress in the immune effect and mechanism of interleukin-36 in fungal keratitis
Fungal keratitis is the most common infectious eye disease with a very high rate of disability and blindness.Its complex immune response system affects the diagnosis,treatment,and prognosis of the disease.Therefore,explo-ring its pathogenesis and the regulatory mechanisms of the body's immune system has become a frontier and key in the field of ophthalmology research today.The latest research indicates that during the process of human corneal epithelial cells and mouse candida albicans(CA)keratitis,interleukin-36γ/IL-36R plays a protective role by mediating innate immunity and Th17 type acquired immunity.This article reviews the recent research progress on the regulatory mecha-nisms of the body's immune protective role after fungal infection of the cornea.
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