Correlation of triglycride-glucose index and atherosclerotic stenosis in intracranial arteries
Objective To investigate the association between the triglyceride-glucose(TyG)index and intracranial ath-erosclerotic stenosis(ICAS)in patients with acute ischaemic stroke(AIS).and to assess the value of the application of TyG index in predicting the occurrence of ICAS in AIS patients.Methods A total of 380 patients with AIS admitted to the Department of Neurology,Shandong Provincial Hospital from December 2021 to December 2023 were selected.They were divided into control group(n＝116)and stenosis group(n＝264)according to the results of digital subtrac-tion angiography(DSA).Baseline data such as medical history,height,body weight,blood pressure,etc.,were col-lected from both groups.Indices such as triglycerides(TG),fasting plasma glucose(FPG),low-density lipoprotein cholesterol(LDL-c),high-density lipoprotein cholesterol(HDL-c)and total cholesterol(TC)were measured.Multi-factorial Logistic regression was used to analyse the risk factors for ICAS in AIS patients.The predictive value of the TyG index for the occurrence of ICAS in patients with AIS was assessed using the receiver operating characteristic(ROC)curve.Results History of hypertension,history of diabetes mellitus,systolic blood pressure,diastolic blood pressure,BMl,TG,FPG and TyG index were increased in the stenosis group compared with the control group,and the difference was statistically significant(P<0.05).The detection rate of ICAS in patients with AIS increased with the in-crease in tertile of TyG index(P<0.05).Spearman's correlation analysis showed that ICAS and history of hypertension,history of diabetes mellitus,systolic blood pressure,diastolic blood pressure,BMl,FPG,TG and TyG index were pos-itively correlated(r values were 0.189,0.273,0.157,0.175,0.142,0.400,0.290 and 0.431,respectively,P<0.05),while ICAS and HDL-c was negatively correlated(r＝-0.248,P<0.05).Two-category Logistic regression analysis showed that TyG index had an independent influence on ICAS(OR＝10.829,95%CI:5.179-22.641,P<0.05),and HDL-c(OR＝0.269,95%CI:0.141-0.514,P<0.05)was a protective factor against ICAS.The ROC curve showed that,the area under the curve of TyG index was 0.777(95%CI:0.723-0.830,P<0.05),which corresponded to a sensitivity of 0.811 and a specificity of 0.629 when the optimal cut-off value of TyG index was 8.625.Conclusion TyG index is associated with ICAS in AIS patients,and high TyG index may be an independent risk factor for ICAS in AIS patients.TyG index has some predictive value for ICAS in AIS patients.
Intracranial artery stenosisIschaemic strokeInsulin resistanceTriglyceride-glucose index
NETL
NSTL
万方数据
